Isolation and structure elucidation of constituents of Citrus limon , Isodon japonicus , and Lansium domesticum as the cancer prevention agents

Table 4 Antimutagenic activity of furanocoumarins (11, 12, 14, and 15) against PhIP (1.0 μg/plate) using the Ames test [4]^a

	Inhibition % (Based on number of revertant colonies)
	3.1 nmol/plate	6.3 nmol/plate	12.5 nmol/plate	25 nmol/plate	50 nmol/plate
Furanocoumarins
11	22.0%	28.0%	29.7%	46.3%	64.0%
12	47.0%	57.7%	68.5%	73.4%	83.4%
14	34.0%	41.7%	51.7%	67.6%	70.1%
15	47.1%	62.1%	65.3%	69.6%	78.7%

^a No compound showed antibacterial activity [< 5.0% inhibition at highest concentration] against the S. typhimurium TA98 strain at the tested concentrations

ISSN: 1880-7062