Fig. 7

Responses of reporter gene assay yeast strains expressing PR (W303a, cwp1Δpdr5Δ, and cwp1Δcwp2Δ) and AR (W303a, cwp1Δpdr5Δ, and pdr5Δpdr10Δ) against progestins from various generations. PR and AR assay yeasts were exposed to MPA (A and B), NET (C and D), LNG (E and F), DSG (G and H), GTD (I and J), DNG (K and L), and DRSP (M and N). Progestational activity (A, C, E, G, I, K, and M) and androgenic activity (B, D, F, H, J, L, and N) were measured. The anti-androgenic activities of DNG (O) and DSRP (P) were also measured by antagonist assays using AR assay yeasts. CYC yeasts (W303a, cwp1Δpdr5Δ, and pdr5Δpdr10Δ) were used as references. Data represent the mean ± SD of triplicate experiments