Ligand
|
E1
|
---|
Yeast strain
|
ERα W303a
|
ERα cwp1Δcwp2Δ
|
ERβ W303a
|
ERβ cwp1Δcwp2Δ
|
---|
Fold difference (10−3 μM)
|
1
|
10.9
|
1
|
4.3
|
Detection limit (μM)
|
10−4
|
10−5
|
10− 4
|
10− 5
|
EC50 (μM)
|
1.20 × 10− 4
|
2.28 × 10− 5
|
2.51 × 10− 4
|
1.50 × 10− 5
|
Ligand
|
E2
|
Yeast strain
|
ERα W303a
|
ERα cwp1Δcwp2Δ
|
ERβ W303a
|
ERβ cwp1Δcwp2Δ
|
Fold difference (10−3 μM)
|
1
|
21.7
|
1
|
5.7
|
Detection limit (μM)
|
10−4
|
10−5
|
10− 4
|
10− 5
|
EC50 (μM)
|
1.84 × 10− 4
|
2.23 × 10− 5
|
1 .42 × 10− 4
|
3.65 × 10− 5
|
Ligand
|
E3
|
Yeast strain
|
ERα W303a
|
ERα cwp1Δcwp2Δ
|
ERβ W303a
|
ERβ cwp1Δcwp2Δ
|
Fold difference (1 μM)
|
1
|
10.1
|
1
|
2.9
|
Detection limit (μM)
|
0.01
|
10−5
|
0.1
|
10−4
|
EC50 (μM)
|
0.15
|
3.02 × 10−5
|
0.034
|
1.22 × 10−3
|
Ligand
|
PS
|
Yeast strain
|
PR W303a
|
PR cwp1Δpdr5Δ
|
PR cwp1Δcwp2Δ
|
Fold difference (10 μM)
|
1
|
34.2
|
29.4
|
Detection limit (μM)
|
10
|
0.01
|
0.01
|
EC50 (μM)
|
2.31
|
0.08
|
0.15
|
Ligand
|
TS
|
Yeast strain
|
AR W303a
|
AR cwp1Δpdr5Δ
|
AR pdr5Δpdr10Δ
|
Fold difference (1 μM)
|
1
|
5.2
|
3.7
|
Detection limit (μM)
|
0.01
|
0.01
|
0.01
|
EC50 (μM)
|
0.024
|
0.021
|
0.013
|
Ligand
|
DHT
|
Yeast strain
|
AR W303a
|
AR cwp1Δpdr5Δ
|
AR pdr5Δpdr10Δ
|
Fold difference (100 μM)
|
1
|
14.4
|
18.6
|
Detection limit (μM)
|
0.01
|
0.01
|
0.01
|
EC50 (μM)
|
0.028
|
0.011
|
0.023
|
- Abbreviation used: EC50, 50% effective concentration