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Table 3 EC50 values (μM) of progestins in yeast strains expressing human PR and AR

From: Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids

Receptor Strains Ligands
MPA NET LNG DSG GTD DNG DRSP
PR W303a n. d. 2.92 n. d. n. d. 0.22 n. c. n. d.
cwp1Δpdr5Δ 9.70 × 10− 3 9.51 × 10− 3 0.023 0.29 9.96 × 10−4 0.86 1.78
cwp1Δcwp2Δ 0.44 0.07 3.06 × 10− 4 0.30 2.59 × 10− 3 6.1 0.80
AR W303a 0.23 0.093 0.030 1.65 n. c. 9.78 n. c.
cwp1Δpdr5Δ 0.28 0.16 0.028 0.32 1.06 8.10 7.39
pdr5Δpdr10Δ 0.084 0.087 0.026 0.31 0.40 2.43 2.32
  1. Abbreviation used: n. d. not detectable, n. c. not calculable