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Table 3 EC50 values (μM) of progestins in yeast strains expressing human PR and AR

From: Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids

Receptor

Strains

Ligands

MPA

NET

LNG

DSG

GTD

DNG

DRSP

PR

W303a

n. d.

2.92

n. d.

n. d.

0.22

n. c.

n. d.

cwp1Δpdr5Δ

9.70 × 10− 3

9.51 × 10− 3

0.023

0.29

9.96 × 10−4

0.86

1.78

cwp1Δcwp2Δ

0.44

0.07

3.06 × 10− 4

0.30

2.59 × 10− 3

6.1

0.80

AR

W303a

0.23

0.093

0.030

1.65

n. c.

9.78

n. c.

cwp1Δpdr5Δ

0.28

0.16

0.028

0.32

1.06

8.10

7.39

pdr5Δpdr10Δ

0.084

0.087

0.026

0.31

0.40

2.43

2.32

  1. Abbreviation used: n. d. not detectable, n. c. not calculable
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Genes and Environment

ISSN: 1880-7062

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