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Fig. 1 | Genes and Environment

Fig. 1

From: The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice

Fig. 1

Endogenous formaldehyde metabolism. Endogenous formaldehyde is mainly detoxified via the ADH5 pathway. Formaldehyde is non-enzymatically bound to GSH, oxidized by ADH5, and further metabolized to formic acid by FGH. ALDH2 exists as an enzyme that redundant to the ADH5-dependent detoxification system. The biological significance of oxidation by other formaldehyde detoxification enzymes such as CYP2E1 and ADH appears to be negligible

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Genes and Environment

ISSN: 1880-7062

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