Table 2 The gpt mutation frequency in the livers of mice administered TiO2-P25 90 days after the last administration
TiO2-P25 | Total population | Number of mutations | Mutation frequency (× 10−6) | |
|---|---|---|---|---|
Mean ± SD | ||||
0 mg/kg | 1,005,000 | 1 | 1.00 | |
1,215,000 | 5 | 4.12 | ||
996,000 | 2 | 2.01 | ||
1,242,000 | 4 | 3.22 | ||
1,074,000 | 4 | 3.72 | ||
1,530,000 | 5 | 3.27 | 2.89 ± 1.17 | |
2 mg/kg | 1,065,000 | 7 | 6.57 | |
468,000 | 8 | 17.09 | ||
1,230,000 | 4 | 3.25 | ||
1,089,000 | 1 | 0.92 | ||
1,446,000 | 4 | 2.77 | ||
1,167,000 | 6 | 5.14 | 5.96 ± 5.80 | |
10 mg/kg | 846,000 | 3 | 6.57 | |
912,000 | 5 | 3.55 | ||
711,000 | 2 | 5.48 | ||
771,000 | 4 | 2.81 | ||
1,506,000 | 2 | 5.19 | ||
1,380,000 | 5 | 1.33 | 3.66 ± 1.54 | |
50 mg/kg | 717,000 | 6 | 8.37 | |
552,000 | 5 | 9.06 | ||
909,000 | 3 | 3.30 | ||
1,011,000 | 5 | 4.95 | ||
1,314,000 | 4 | 3.04 | 5.74 ± 2.82 | |