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Table 3 The Spi mutant frequency in the livers of mice administered TiO2-P25 90 d after the last administration

From: Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver of gpt delta transgenic mice

TiO2-P25Total populationNumber of mutantsMutant frequency (×10−5)
 Mean ± SD
0 mg/kg1,113,000141.26 
1,326,000201.51 
513,000101.95 
1,185,000131.10 
951,000242.52 
1,035,000141.351.61 ± 0.53
2 mg/kg594,000162.69 
972,000171.75 
855,000141.64 
774,000131.68 
1,344,000332.46 
1,023,000201.962.03 ± 0.43
10 mg/kg663,000101.51 
738,000101.36 
1,404,000161.14 
1,584,000171.07 
1,440,000805.56 
738,000111.492.02 ± 1.74
50 mg/kg1,332,000201.50 
345,00010.29 
1,572,000140.89 
1,026,000171.66 
915,000171.861.24 ± 0.64