Table 3 The Spi− mutant frequency in the livers of mice administered TiO2-P25 90 d after the last administration
TiO2-P25 | Total population | Number of mutants | Mutant frequency (×10−5) | |
|---|---|---|---|---|
Mean ± SD | ||||
0 mg/kg | 1,113,000 | 14 | 1.26 | |
1,326,000 | 20 | 1.51 | ||
513,000 | 10 | 1.95 | ||
1,185,000 | 13 | 1.10 | ||
951,000 | 24 | 2.52 | ||
1,035,000 | 14 | 1.35 | 1.61 ± 0.53 | |
2 mg/kg | 594,000 | 16 | 2.69 | |
972,000 | 17 | 1.75 | ||
855,000 | 14 | 1.64 | ||
774,000 | 13 | 1.68 | ||
1,344,000 | 33 | 2.46 | ||
1,023,000 | 20 | 1.96 | 2.03 ± 0.43 | |
10 mg/kg | 663,000 | 10 | 1.51 | |
738,000 | 10 | 1.36 | ||
1,404,000 | 16 | 1.14 | ||
1,584,000 | 17 | 1.07 | ||
1,440,000 | 80 | 5.56 | ||
738,000 | 11 | 1.49 | 2.02 ± 1.74 | |
50 mg/kg | 1,332,000 | 20 | 1.50 | |
345,000 | 1 | 0.29 | ||
1,572,000 | 14 | 0.89 | ||
1,026,000 | 17 | 1.66 | ||
915,000 | 17 | 1.86 | 1.24 ± 0.64 | |