Table 1 Mutation spectra of the gpt gene in testes of the AA-treated mice
From: Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice
|  | 28 + 3d | 28 + 49d | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 mg/kg/day | 7.5 mg/kg/day | 15 mg/kg/day | 30 mg/kg/day | 0 mg/kg/day | 7.5 mg/kg/day | 15 mg/kg/day | 30 mg/kg/day | |||||||||||||||||
No. | % | MF (×10− 6) | No. | % | MF (×10− 6) | No. | % | MF (× 10− 6) | No. | % | MF (× 10− 6) | No. | % | MF (× 10− 6) | No. | % | MF (× 10− 6) | No. | % | MF (× 10− 6) | No. | % | MF (×10−6) | |
Base substitution | ||||||||||||||||||||||||
 Transition | ||||||||||||||||||||||||
  G:C to A:T | 1 | 16.7 | 0.21 | 6 | 66.7 | 1.11 | 4 | 44.4 | 0.50 | 6 | 30.0 | 0.82 | 1 | 33.3 | 0.24 | 1 | 33.3 | 0.20 | 4 | 36.4 | 0.48 | 8 | 50.0 | 1.02 |
   at CpG site | (0) |  |  | (2) |  |  | (1) |  |  | (2) |  |  | (0) |  |  | (0) |  |  | (1) |  |  | (6) |  |  |
  A:T to G:C | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 1 | 5.0 | 0.14 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
 Transversion | ||||||||||||||||||||||||
  G:C to T:A | 1 | 16.7 | 0.21 | 0 | 0.0 | 0.00 | 2 | 22.2 | 0.25 | 4 | 20.0 | 0.54 | 1 | 33.3 | 0.24 | 2 | 66.7 | 0.40 | 4 | 36.4 | 0.48 | 2 | 12.5 | 0.25 |
  G:C to C:G | 1 | 16.7 | 0.21 | 0 | 0.0 | 0.00 | 1 | 11.1 | 0.12 | 2 | 10.0 | 0.27 | 1 | 33.3 | 0.24 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
  A:T to T:A | 0 | 0.0 | 0.00 | 3 | 33.3 | 0.55 | 0 | 0.0 | 0.00 | 3 | 15.0 | 0.41 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
  A:T to C:G | 1 | 16.7 | 0.21 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
Deletion | 2 | 33.3 | 0.42 | 0 | 0.0 | 0.00 | 1 | 11.1 | 0.12 | 3 | 15.0 | 0.41 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 3 | 27.3 | 0.36 | 4 | 25.0 | 0.51 |
 1 bp | 2 |  |  | 0 |  |  | 0 |  |  | 2 |  |  | 0 |  |  | 0 |  |  | 3 |  |  | 4 |  |  |
  > 2 bps | 0 |  |  | 0 |  |  | 1 |  |  | 1 |  |  | 0 |  |  | 0 |  |  | 0 |  |  | 0 |  |  |
Insertion | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 1 | 11.1 | 0.12 | 1 | 5.0 | 0.14 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 2 | 12.5 | 0.25 |
Other | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
Total | 6 | 100 | 1.27 | 9 | 100 | 1.66 | 9 | 100 | 1.12 | 20 | 100 | 2.72 | 3 | 100 | 0.71 | 3 | 100 | 0.60 | 11 | 100 | 1.33 | 16 | 100 | 2.03 |