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Table 1 Mutation spectra of the gpt gene in testes of the AA-treated mice

From: Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice

  28 + 3d 28 + 49d
0 mg/kg/day 7.5 mg/kg/day 15 mg/kg/day 30 mg/kg/day 0 mg/kg/day 7.5 mg/kg/day 15 mg/kg/day 30 mg/kg/day
No. % MF (×10− 6) No. % MF (×10− 6) No. % MF (× 10− 6) No. % MF (× 10− 6) No. % MF (× 10− 6) No. % MF (× 10− 6) No. % MF (× 10− 6) No. % MF (×10−6)
Base substitution
 Transition
  G:C to A:T 1 16.7 0.21 6 66.7 1.11 4 44.4 0.50 6 30.0 0.82 1 33.3 0.24 1 33.3 0.20 4 36.4 0.48 8 50.0 1.02
   at CpG site (0)    (2)    (1)    (2)    (0)    (0)    (1)    (6)   
  A:T to G:C 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 1 5.0 0.14 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00
 Transversion
  G:C to T:A 1 16.7 0.21 0 0.0 0.00 2 22.2 0.25 4 20.0 0.54 1 33.3 0.24 2 66.7 0.40 4 36.4 0.48 2 12.5 0.25
  G:C to C:G 1 16.7 0.21 0 0.0 0.00 1 11.1 0.12 2 10.0 0.27 1 33.3 0.24 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00
  A:T to T:A 0 0.0 0.00 3 33.3 0.55 0 0.0 0.00 3 15.0 0.41 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00
  A:T to C:G 1 16.7 0.21 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00
Deletion 2 33.3 0.42 0 0.0 0.00 1 11.1 0.12 3 15.0 0.41 0 0.0 0.00 0 0.0 0.00 3 27.3 0.36 4 25.0 0.51
 1 bp 2    0    0    2    0    0    3    4   
  > 2 bps 0    0    1    1    0    0    0    0   
Insertion 0 0.0 0.00 0 0.0 0.00 1 11.1 0.12 1 5.0 0.14 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 2 12.5 0.25
Other 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00
Total 6 100 1.27 9 100 1.66 9 100 1.12 20 100 2.72 3 100 0.71 3 100 0.60 11 100 1.33 16 100 2.03