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Table 2 Mutation spectra of the gpt gene in sperm of the AA-treated mice

From: Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice

  28 + 3d 28 + 49d
0 mg/kg/day 30 mg/kg/day 0 mg/kg/day 30 mg/kg/day
No. % MF (×10−6) No. % MF (×10−6) No. % MF (×10−6) No. % MF (×10−6)
Base substitution
 Transition
  G:C to A:T 4 50.0 0.59 7 31.8 2.15 8 72.7 1.36 6 50.0 0.67
   at CpG site (2)    (5)    (4)    (4)   
  A:T to G:C 0 0.0 0.00 1 4.5 0.31 1 9.1 0.17 1 8.3 0.11
 Transversion
  G:C to T:A 1 12.5 0.15 6 27.3 1.85* 0 0.0 0.00 2 16.7 0.22
  G:C to C:G 0 0.0 0.00 1 4.5 0.31 0 0.0 0.00 0 0.0 0.00
  A:T to T:A 1 12.5 0.15 1 4.5 0.31 0 0.0 0.00 1 8.3 0.11
  A:T to C:G 0 0.0 0.00 1 4.5 0.31 0 0.0 0.00 0 0.0 0.00
Deletion 2 25.0 0.30 4 18.2 1.23 2 18.2 0.34 2 16.7 0.22
 1 bp 1    3    2    1   
  > 2 bps 1    1    0    1   
Insertion 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00
Other 0 0.0 0.00 1 4.5 0.31 0 0.0 0.00 0 0.0 0.00
Total 8 100 1.18 22 100 6.77 11 100 1.87 12 100 1.34
  1. *p < 0.05 vs control