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Table 2 Mutation spectra of the gpt gene in sperm of the AA-treated mice

From: Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice

 

28 + 3d

28 + 49d

0 mg/kg/day

30 mg/kg/day

0 mg/kg/day

30 mg/kg/day

No.

%

MF (×10−6)

No.

%

MF (×10−6)

No.

%

MF (×10−6)

No.

%

MF (×10−6)

Base substitution

 Transition

  G:C to A:T

4

50.0

0.59

7

31.8

2.15

8

72.7

1.36

6

50.0

0.67

   at CpG site

(2)

  

(5)

  

(4)

  

(4)

  

  A:T to G:C

0

0.0

0.00

1

4.5

0.31

1

9.1

0.17

1

8.3

0.11

 Transversion

  G:C to T:A

1

12.5

0.15

6

27.3

1.85*

0

0.0

0.00

2

16.7

0.22

  G:C to C:G

0

0.0

0.00

1

4.5

0.31

0

0.0

0.00

0

0.0

0.00

  A:T to T:A

1

12.5

0.15

1

4.5

0.31

0

0.0

0.00

1

8.3

0.11

  A:T to C:G

0

0.0

0.00

1

4.5

0.31

0

0.0

0.00

0

0.0

0.00

Deletion

2

25.0

0.30

4

18.2

1.23

2

18.2

0.34

2

16.7

0.22

 1 bp

1

  

3

  

2

  

1

  

  > 2 bps

1

  

1

  

0

  

1

  

Insertion

0

0.0

0.00

0

0.0

0.00

0

0.0

0.00

0

0.0

0.00

Other

0

0.0

0.00

1

4.5

0.31

0

0.0

0.00

0

0.0

0.00

Total

8

100

1.18

22

100

6.77

11

100

1.87

12

100

1.34

  1. *p < 0.05 vs control