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Table 3 Mutation spectra of the gpt gene in lung of the AA-treated mice

From: Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice

  28 + 3d 28 + 49d
0 mg/kg/day 30 mg/kg/day 0 mg/kg/day 30 mg/kg/day
No. % MF (×10−6) No. % MF (×10−6) No. % MF (×10−6) No. % MF (×10−6)
Base substitution
 Transition
  G:C to A:T 6 27.3 0.65 10 30.3 1.54 7 46.7 0.95 14 33.3 2.18
   at CpG site (5)    (8)    (4)    (7)   
  A:T to G:C 1 4.5 0.11 1 3.0 0.15 1 6.7 0.14 7 16.7 1.09
 Transversion
  G:C to T:A 7 31.8 0.76 3 9.1 0.46 3 20.0 0.41 4 9.5 0.62
  G:C to C:G 1 4.5 0.11 0 0.0 0.00 0 0.0 0.00 2 4.8 0.31
  A:T to T:A 0 0.0 0.00 5 15.2 0.77* 0 0.0 0.00 8 19.0 1.25*
  A:T to C:G 1 4.5 0.11 3 9.1 0.46 0 0.0 0.00 1 2.4 0.16
Deletion 6 27.3 0.65 10 30.3 1.54 4 26.7 0.54 5 11.9 0.78
 1 bp 5    10    3    5   
  > 2 bps 1    0    1    0   
Insertion 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00 0 0.0 0.00
Other 0 0.0 0.00 1 3.0 0.15 0 0.0 0.00 1 2.4 0.16
Total 22 100 2.40 33 100 5.09 15 100 2.03 42 100 6.54
  1. *Significantly different from control (p < 0.05)