Table 3 Mutation spectra of the gpt gene in lung of the AA-treated mice
From: Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice
| 28 + 3d | 28 + 49d | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 mg/kg/day | 30 mg/kg/day | 0 mg/kg/day | 30 mg/kg/day | |||||||||
| No. | % | MF (×10−6) | No. | % | MF (×10−6) | No. | % | MF (×10−6) | No. | % | MF (×10−6) | |
| Base substitution | ||||||||||||
| Transition | ||||||||||||
| G:C to A:T | 6 | 27.3 | 0.65 | 10 | 30.3 | 1.54 | 7 | 46.7 | 0.95 | 14 | 33.3 | 2.18 |
| at CpG site | (5) | (8) | (4) | (7) | ||||||||
| A:T to G:C | 1 | 4.5 | 0.11 | 1 | 3.0 | 0.15 | 1 | 6.7 | 0.14 | 7 | 16.7 | 1.09 |
| Transversion | ||||||||||||
| G:C to T:A | 7 | 31.8 | 0.76 | 3 | 9.1 | 0.46 | 3 | 20.0 | 0.41 | 4 | 9.5 | 0.62 |
| G:C to C:G | 1 | 4.5 | 0.11 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 2 | 4.8 | 0.31 |
| A:T to T:A | 0 | 0.0 | 0.00 | 5 | 15.2 | 0.77* | 0 | 0.0 | 0.00 | 8 | 19.0 | 1.25* |
| A:T to C:G | 1 | 4.5 | 0.11 | 3 | 9.1 | 0.46 | 0 | 0.0 | 0.00 | 1 | 2.4 | 0.16 |
| Deletion | 6 | 27.3 | 0.65 | 10 | 30.3 | 1.54 | 4 | 26.7 | 0.54 | 5 | 11.9 | 0.78 |
| 1 bp | 5 | 10 | 3 | 5 | ||||||||
| > 2 bps | 1 | 0 | 1 | 0 | ||||||||
| Insertion | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
| Other | 0 | 0.0 | 0.00 | 1 | 3.0 | 0.15 | 0 | 0.0 | 0.00 | 1 | 2.4 | 0.16 |
| Total | 22 | 100 | 2.40 | 33 | 100 | 5.09 | 15 | 100 | 2.03 | 42 | 100 | 6.54 |