Skip to main content

Table 5 Comparison of genotypes with various end points studied. Average DNA damage (%T) for 2.0 Gy at 0 h and 4 h post irradiation (after 4 h) and relative expression (for 2.0 Gy after 4 h) in PBMCs of adaptive and non-adaptive donors

From: Radio-adaptive response and correlation of non-homologous end joining repair gene polymorphisms [XRRC5 (3R/2R/1R/0R), XRCC6(C/G) and XRCC7 (G/T)] in human peripheral blood mononuclear cells exposed to gamma radiation

Genotypes Adaptive individuals (N = 16) Non-adaptive individuals (N = 4)
(N, frequency %) Average %T at 2.0 Gy
(0 h) ± SD
Average %T at 2.0 Gy
(after 4 h) ± SD
Average relative expression at 2.0Gy (after 4 h) ± SD (N, frequency %) Average %T at 2.0Gy
(0 h) ± SD
Average %T at 2.0 Gy
(after 4 h) ± SD
Average relative expression at 2.0 Gy (after 4 h) ± SD
XRCC5 (0R/1R/2R/3R)
0R/1R 0 (0.00%) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 1 (25.00%) 9.36 ± 0.00 2.20 ± 0.00 0.79 ± 0.00
0R/2R 0 (0.00%) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 1 (25.00%) 10.37 ± 0.00 3.58 ± 0.00 1.12 ± 0.00
1R/1R 7 (43.75%) 6.81 ± 1.03 3.43 ± 0.53 1.11 ± 0.30 1 (25.00%) 8.98 ± 0.00 3.91 ± 0.00 1.12 ± 0.00
1R/2R 5 (31.25%) 6.42 ± 0.32 4.11 ± 0.10 1.04 ± 0.13 1 (25.00%) 9.55 ± 0.00 2.92 ± 0.00 1.04 ± 0.00
2R/2R 4 (25.00%) 7.41 ± 1.23 3.81 ± 0.73 1.27 ± 0.28 0 (0.00%) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
XRCC6 (C/G)
CC 7 (43.75%) 7.42 ± 0.98 3.80 ± 0.59 1.24 ± 0.40 3 (75.0%) 9.57 ± 0.72 3.23 ± 0.91 1.03 ± 0.24
CG 7 (43.75%) 6.38 ± 0.75 3.54 ± 0.55 1.27 ± 0.22 1 (25.0%) 9.55 ± 0.00 2.92 ± 0.00 0.95 ± 0.00
GG 2 (12.50%) 6.42 ± 0.01 4.14 ± 0.08 1.10 ± 0.04 0 (0.0%) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
XRCC7 (G/T)
TT 4 (25.00%) 6.62 ± 0.95 3.87 ± 0.32 0.83 ± 0.24 1 (25.0%) 9.55 ± 0.00 2.92 ± 0.00 0.82 ± 0.00
TG 10 (62.50%) 6.72 ± 0.82 3.55 ± 0.57 1.08 ± 0.24 1 (25.0%) 10.37 ± 0.00 3.58 ± 0.00 1.14 ± 0.00
GG 2 (12.50%) 7.92 ± 1.42 4.34 ± 0.36 1.05 ± 0.06 2 (50.0%) 9.17 ± 0.27 3.05 ± 1.21 1.02 ± 0.04
  1. “N” indicates number of donors showing a particular genotype, SD Standard Deviation