Table 5 Comparison of genotypes with various end points studied. Average DNA damage (%T) for 2.0 Gy at 0 h and 4 h post irradiation (after 4 h) and relative expression (for 2.0 Gy after 4 h) in PBMCs of adaptive and non-adaptive donors
Genotypes | Adaptive individuals (N = 16) | Non-adaptive individuals (N = 4) | ||||||
|---|---|---|---|---|---|---|---|---|
(N, frequency %) | Average %T at 2.0 Gy (0 h) ± SD | Average %T at 2.0 Gy (after 4 h) ± SD | Average relative expression at 2.0Gy (after 4 h) ± SD | (N, frequency %) | Average %T at 2.0Gy (0 h) ± SD | Average %T at 2.0 Gy (after 4 h) ± SD | Average relative expression at 2.0 Gy (after 4 h) ± SD | |
XRCC5 (0R/1R/2R/3R) | ||||||||
0R/1R | 0 (0.00%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 1 (25.00%) | 9.36 ± 0.00 | 2.20 ± 0.00 | 0.79 ± 0.00 |
0R/2R | 0 (0.00%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 1 (25.00%) | 10.37 ± 0.00 | 3.58 ± 0.00 | 1.12 ± 0.00 |
1R/1R | 7 (43.75%) | 6.81 ± 1.03 | 3.43 ± 0.53 | 1.11 ± 0.30 | 1 (25.00%) | 8.98 ± 0.00 | 3.91 ± 0.00 | 1.12 ± 0.00 |
1R/2R | 5 (31.25%) | 6.42 ± 0.32 | 4.11 ± 0.10 | 1.04 ± 0.13 | 1 (25.00%) | 9.55 ± 0.00 | 2.92 ± 0.00 | 1.04 ± 0.00 |
2R/2R | 4 (25.00%) | 7.41 ± 1.23 | 3.81 ± 0.73 | 1.27 ± 0.28 | 0 (0.00%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
XRCC6 (C/G) | ||||||||
CC | 7 (43.75%) | 7.42 ± 0.98 | 3.80 ± 0.59 | 1.24 ± 0.40 | 3 (75.0%) | 9.57 ± 0.72 | 3.23 ± 0.91 | 1.03 ± 0.24 |
CG | 7 (43.75%) | 6.38 ± 0.75 | 3.54 ± 0.55 | 1.27 ± 0.22 | 1 (25.0%) | 9.55 ± 0.00 | 2.92 ± 0.00 | 0.95 ± 0.00 |
GG | 2 (12.50%) | 6.42 ± 0.01 | 4.14 ± 0.08 | 1.10 ± 0.04 | 0 (0.0%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
XRCC7 (G/T) | ||||||||
TT | 4 (25.00%) | 6.62 ± 0.95 | 3.87 ± 0.32 | 0.83 ± 0.24 | 1 (25.0%) | 9.55 ± 0.00 | 2.92 ± 0.00 | 0.82 ± 0.00 |
TG | 10 (62.50%) | 6.72 ± 0.82 | 3.55 ± 0.57 | 1.08 ± 0.24 | 1 (25.0%) | 10.37 ± 0.00 | 3.58 ± 0.00 | 1.14 ± 0.00 |
GG | 2 (12.50%) | 7.92 ± 1.42 | 4.34 ± 0.36 | 1.05 ± 0.06 | 2 (50.0%) | 9.17 ± 0.27 | 3.05 ± 1.21 | 1.02 ± 0.04 |