TY - JOUR AU - Yasui, Manabu AU - Fukuda, Takayuki AU - Ukai, Akiko AU - Maniwa, Jiro AU - Imamura, Tadashi AU - Hashizume, Tsuneo AU - Yamamoto, Haruna AU - Shibuya, Kaori AU - Narumi, Kazunori AU - Fujiishi, Yohei AU - Okada, Emiko AU - Fujishima, Saori AU - Yamamoto, Mika AU - Otani, Naoko AU - Nakamura, Maki AU - Nishimura, Ryoichi AU - Ueda, Maya AU - Mishima, Masayuki AU - Matsuzaki, Kaori AU - Takeiri, Akira AU - Tanaka, Kenji AU - Okada, Yuki AU - Nakagawa, Munehiro AU - Hamada, Shuichi AU - Kajikawa, Akihiko AU - Honda, Hiroshi AU - Adachi, Jun AU - Misaki, Kentaro AU - Ogawa, Kumiko AU - Honma, Masamitsu PY - 2021 DA - 2021/03/06 TI - Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS JO - Genes and Environment SP - 7 VL - 43 IS - 1 AB - Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are thought to be an advantage as follow-up studies for positive results in Ames tests. In this collaborative study, a thymidine kinase gene mutation study (TK6 assay) using human lymphoblastoid TK6 cells, established in OECD TG490, was used to examine 10 chemicals that have conflicting results in mutagenicity studies (a positive Ames test and a negative result in rodent carcinogenicity studies). SN - 1880-7062 UR - https://doi.org/10.1186/s41021-021-00179-1 DO - 10.1186/s41021-021-00179-1 ID - Yasui2021 ER -