No. | Chemical Name | The Positive Results in Bacterial Reverse Mutation Assay | Carcinogenicity Studies | ||||
---|---|---|---|---|---|---|---|
Without S9 | With S9 | The Highest Specific Activityb and the Strain | Ref. | Â | Ref. | ||
1 | 4-(Chloroacetyl)-acetanilide | Neg | Pos | 600 revertants/mg in TA1538 with S9 | Neg | [20] | |
2 | 2-(Chloromethyl) pyridine HCl | Pos | Pos | 98.6 revertants/mg in TA100 with S9 | [21] | Neg | [22] |
3 | 2,6-Diaminotoluene | Neg | Pos | 1703 revertants/mg in TA100 with S9 | [23] | Neg | [24] |
4 | 2,5-Diaminotoluene | Neg | Pos | 8060 revertants/mg in TA98 and 3840 revertants/mg in TA100 with S9 | [25] | Neg | [26] |
5 | HC Blue No.2 | Pos | Pos | 153.6 revertants/mg in TA98 with S9 | Neg | [29] | |
6 | 8-Hydroxyquinoline | Neg | Pos | 21,400 revertants/mg in TA97 and 16,000 revertants/mg in TA100 with S9 | [28] | Neg | [30] |
7 | Iodoform | Pos | Pos | 465 revertants/mg in TA98 and 450 revertants/mg in TA100 with S9 | [31] | Neg | [32] |
8 | 4-Nitroanthranilic acid | Pos | Pos | 3600 revertants/mg in TA1535 and 2830 revertants/mg in TA100 with S9 | [33] | Neg | [34] |
9 | 1-Nitronaphthalene | Pos | Pos | 14,700 revertants/mg in TA100 without S9 and 12,500 revertants/mg in TA100 with S9 | [35] | Neg | [36] |
10 | 4-Nitro-o-phenylenediamine | Pos | Pos | 41,400 revertants/mg in TA100 without S9 | Neg | [41] |