Fig. 2
CHL and natural chlorophyll a (Chla) act as interceptor molecules against aflatoxin B1 (AFB1). a Antimutagenic activity of CHL against AFB1–8,9-epoxide in the Salmonella assay, in the absence of a metabolic activation system, with complex formation supported by molecular docking in silico. b CHL inhibits AFB1-DNA binding and hepatocellular carcinoma in rainbow trout, and is more effective than Chla at inhibiting AFB1-DNA adducts in trout liver (****P < 0.0001, ***P < 0.001). c CHL and Chla inhibit AFB1-DNA adducts in rat liver (**P < 0.01). d Accelerator mass spectrometry revealed that oral administration of CHL or Chla both lowered AFB1 uptake and bioavailability in human volunteers. This work highlights the continuum from mechanistic to preclinical to human translational findings [14, 28,29,30,31,32,33,34,35,36]