No. | JECFA No. | Chemical Name | CAS No. | Judgement after review | Key reference* | Comments |
---|---|---|---|---|---|---|
1 | 252 | isobutanal | 78–84-2 | Negative | [13] | The study condition did not meet current standard. Other available data indicative of negative. |
2 | 690 | phenol | 108–95-2 | Negative | [14] | Only one positive report of which response was weak. Other available data indicative of negative. |
3 | 738 | furfuryl alcohol | 98–00-0 | Negative | [15] | Only one report was positive among 6 reports reviewed in the key reference. Although no detail was available, the study conditon is unlikely meet current standard. |
4 | 744 | furfural | 98–01-1 | Negative | [15] | Among 14 reports reviewed in the key reference, 4 reports indicative of positive were questionable. Other 10 reports were negative. |
5 | 836 | 2-hydroxy-1,2-diphenylethanone | 119–53-9 | Inconclusive | [16] | Weak positive. Other available data are a mixture of positives/negatives. No conclusion drawn. |
6 | 1168 | 3-propylidenephthalide | 17,369–59-4 | Inconclusive | [17] | One positive report reviewed in the key reference raised a question about purity. Other available data were also unclear. |
7 | 1172 | 6-methylcoumarin | 92–48-8 | Negative | [18] | Ambiguous response. Other available data indicative of negative. |
8 | 1342 | delta-3-carene | 13,466–78-9 | Inconclusive | [19] | Positve though not meeting current standard. Recent other data (Saverni, 2012) indicative of negative. No conclusion drawn. |
9 | 1450 | 4-hydroxy-5-methyl-3(2H)-furanone | 19,322–27-1 | Positive | [20] | Confirmed positive response. No other data negate the conclusion was available. |
10 | 1481 | ethyl maltol | 4940-11-8 | Inconclusive | [21] | Two conflicting reports reviewed in the key reference. No conclusion drawn. |
11 | 1560 | allyl isothiocyanate | 57–06-7 | Positive | [22] | Weak positive. Other available data are a mixture of positives/negatives. “Isothiocyanate” structure adopted as “positve alert” in representative QSAR tools. |
12 | 1561 | butyl isothiocyanate | 592–82-5 | Positive | [23] | Confirmed positive response. No other data negate the conclusion was available. |
13 | 1563 | phenethyl isothiocyanate | 2257–09-2 | Positive | [22] | Weak positive. Other available data also indicate positive. |
14 | 1776 | ethyl 2-[(5-methyl-2-propan-2-yl cyclohexanecarbonyl)amino]acetate | 68,489–14-5 | Negative | [15] | Since the study report indicative of weak positive reviewed in the key reference was unpublished, no reliability confirmed. Recent GLP data submitted to MHLW under ANEI-HOU was negative (undisclosed). |