Skip to main content

Table 1 Re-evaluation of Ames test data, which were categorized as “equivocal” by Ono et al. [4]

From: Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™

No. JECFA No. Chemical Name CAS No. Judgement after review Key reference* Comments
1 252 isobutanal 78–84-2 Negative [13] The study condition did not meet current standard. Other available data indicative of negative.
2 690 phenol 108–95-2 Negative [14] Only one positive report of which response was weak. Other available data indicative of negative.
3 738 furfuryl alcohol 98–00-0 Negative [15] Only one report was positive among 6 reports reviewed in the key reference. Although no detail was available, the study conditon is unlikely meet current standard.
4 744 furfural 98–01-1 Negative [15] Among 14 reports reviewed in the key reference, 4 reports indicative of positive were questionable. Other 10 reports were negative.
5 836 2-hydroxy-1,2-diphenylethanone 119–53-9 Inconclusive [16] Weak positive. Other available data are a mixture of positives/negatives. No conclusion drawn.
6 1168 3-propylidenephthalide 17,369–59-4 Inconclusive [17] One positive report reviewed in the key reference raised a question about purity. Other available data were also unclear.
7 1172 6-methylcoumarin 92–48-8 Negative [18] Ambiguous response. Other available data indicative of negative.
8 1342 delta-3-carene 13,466–78-9 Inconclusive [19] Positve though not meeting current standard. Recent other data (Saverni, 2012) indicative of negative. No conclusion drawn.
9 1450 4-hydroxy-5-methyl-3(2H)-furanone 19,322–27-1 Positive [20] Confirmed positive response. No other data negate the conclusion was available.
10 1481 ethyl maltol 4940-11-8 Inconclusive [21] Two conflicting reports reviewed in the key reference. No conclusion drawn.
11 1560 allyl isothiocyanate 57–06-7 Positive [22] Weak positive. Other available data are a mixture of positives/negatives. “Isothiocyanate” structure adopted as “positve alert” in representative QSAR tools.
12 1561 butyl isothiocyanate 592–82-5 Positive [23] Confirmed positive response. No other data negate the conclusion was available.
13 1563 phenethyl isothiocyanate 2257–09-2 Positive [22] Weak positive. Other available data also indicate positive.
14 1776 ethyl 2-[(5-methyl-2-propan-2-yl cyclohexanecarbonyl)amino]acetate 68,489–14-5 Negative [15] Since the study report indicative of weak positive reviewed in the key reference was unpublished, no reliability confirmed. Recent GLP data submitted to MHLW under ANEI-HOU was negative (undisclosed).
  1. * Reference that was considered as a basis to draw a conclusion of “equivocal”.