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Table 1 Re-evaluation of Ames test data, which were categorized as “equivocal” by Ono et al. [4]

From: Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™

No.

JECFA No.

Chemical Name

CAS No.

Judgement after review

Key reference*

Comments

1

252

isobutanal

78–84-2

Negative

[13]

The study condition did not meet current standard. Other available data indicative of negative.

2

690

phenol

108–95-2

Negative

[14]

Only one positive report of which response was weak. Other available data indicative of negative.

3

738

furfuryl alcohol

98–00-0

Negative

[15]

Only one report was positive among 6 reports reviewed in the key reference. Although no detail was available, the study conditon is unlikely meet current standard.

4

744

furfural

98–01-1

Negative

[15]

Among 14 reports reviewed in the key reference, 4 reports indicative of positive were questionable. Other 10 reports were negative.

5

836

2-hydroxy-1,2-diphenylethanone

119–53-9

Inconclusive

[16]

Weak positive. Other available data are a mixture of positives/negatives. No conclusion drawn.

6

1168

3-propylidenephthalide

17,369–59-4

Inconclusive

[17]

One positive report reviewed in the key reference raised a question about purity. Other available data were also unclear.

7

1172

6-methylcoumarin

92–48-8

Negative

[18]

Ambiguous response. Other available data indicative of negative.

8

1342

delta-3-carene

13,466–78-9

Inconclusive

[19]

Positve though not meeting current standard. Recent other data (Saverni, 2012) indicative of negative. No conclusion drawn.

9

1450

4-hydroxy-5-methyl-3(2H)-furanone

19,322–27-1

Positive

[20]

Confirmed positive response. No other data negate the conclusion was available.

10

1481

ethyl maltol

4940-11-8

Inconclusive

[21]

Two conflicting reports reviewed in the key reference. No conclusion drawn.

11

1560

allyl isothiocyanate

57–06-7

Positive

[22]

Weak positive. Other available data are a mixture of positives/negatives. “Isothiocyanate” structure adopted as “positve alert” in representative QSAR tools.

12

1561

butyl isothiocyanate

592–82-5

Positive

[23]

Confirmed positive response. No other data negate the conclusion was available.

13

1563

phenethyl isothiocyanate

2257–09-2

Positive

[22]

Weak positive. Other available data also indicate positive.

14

1776

ethyl 2-[(5-methyl-2-propan-2-yl cyclohexanecarbonyl)amino]acetate

68,489–14-5

Negative

[15]

Since the study report indicative of weak positive reviewed in the key reference was unpublished, no reliability confirmed. Recent GLP data submitted to MHLW under ANEI-HOU was negative (undisclosed).

  1. * Reference that was considered as a basis to draw a conclusion of “equivocal”.