Fig. 4

Quantities of DNA adducts in tumor and nontumor sites. Box plots of the molar ratio of DNA adducts in tumor or nontumor sites in gastric cancer subjects (GC tumor and GC nontumor) or in the stomachs of nongastric cancer subjects (non-GC) (a: C5-methyl-dC, b: dI, c: C5-hydroxymethyl-dC, d: N6-methyl-dA, e: etheno-dA, f: N6-hydroxymethyl-dA, g: C8-oxo-dG). The center line of the box indicates the median, and the top and bottom edges of the box indicate IQR. The whiskers show the maximum or minimum within a range of 1.5 times the IQR from the edge of the box. Outliers are indicated by circles (°) that are 1.5 to 3 times the IQR from the top or the bottom of a box and by stars (*) that are more than 3 times the IQR from the top or the bottom of a box. Kruskal-Wallis tests for the three groups and Bonferroni-corrected Mann-Whitney U tests for pairwise comparisons of the three groups confirmed the significant differences in 2 DNA adducts with adjusted p-values (adj. p) less than 0.05 (c, g). Zero values were excluded from the box plots