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Table 1 all of the aberrant methylations which have been reported among Iranian cancer patients

From: Methylation as a critical epigenetic process during tumor progressions among Iranian population: an overview

Gene Year Type population sample Results study (ET AL)
dna repair
 MGMT, CDH1 2010 Oral 57N/76Ta Tissue Hyper methylation. Kordi-Tamandan [30]
 MGMT, BRCA-1 2019 Breast 27 MTb
31 BTc
Tissue Hyper methylation in MT. Paydar [31]
 MGMT, p53 2009 Glioblastoma 50 patients Tissue MGMT hyper methylation was correlated with p53 expression. Shamsara [32]
 MGMT 2013 Colorectal 40 patients
30 controls
Tissue Hyper methylation. Farzanehfar [33]
 MGMT 2018 Colorectal 70 patients Serum Hyper methylation. Alizadeh Naini [34]
 hMLH1, CDH1 2014 Gastric 51 patients Tissue Hyper methylations were correlated with stage. Moghbeli [35]
cell adhesion
 RASSF6, RASSF10 2017 Lymphoblastic leukemia 45 patients Blood Hyper methylation. Younesian [36]
 HIC1,RASSF1A 2009 Breast 81 patients
100 controls
Tissue Hyper methylation. Rasti [37]
 P16, TSHR, RASSF1A, 2011 Thyroid 25MT
25BT
Tissue Hyper methylation. Mohammadi-asl [38]
 Integrin a4, CDH1 2015 Prostate 30 patients
40 benign
Tissue Hyper methylation. Mostafavi-Pour [39]
 CDH1 2016 Breast 98T/10N Tissue Hyper methylation. Naghitorabi [40]
 CDH1 2014 Breast 50 N/T Tissue Hyper methylation. Shargh [41]
 SPG20 2017 Colorectal 32 N/T Serum Hyper methylation. Rezvani [42]
cell cycle
 P14ARF 2010 Oral 76 patients
57 controls
Tissue Hyper methylation. Kordi-Tamandani [43]
 P16INK4a, p53, p16, MDM2 2010 Esophageal 50 N/T Tissue P16 hyper methylation was correlated with p53 expression. Taghavi [44]
 P16 2005 Esophageal 58 patients
30 controls
Blood Hyper methylation. Abbaszadegan [45]
 P16 2018 Oral 67 patients
59 controls
Tissue Hyper methylation was correlated with grade. Allameh [46]
 P15INK4a, p16INK4a 2012 Oral   Tissue Hyper methylation. Kordi-Tamandani [47]
 P16 2009 Breast 70 patients   Hyper methylation. Vallian [48]
 P16 2008 Gastric 52 patients
50 controls
Serum Hyper methylation. Abbaszadegan [49]
 DBC2 2012 Breast 50 patients
35 controls
Tissue Hyper methylation. Hajikhan Mirzaei [50]
 14-3-3 sigma 2012 Breast 20 patients
20 controls
Tissue Hyper methylation. Gheibi [51]
 UBE2Q1, UBE2Q2 2015 Colorectal 60 N/T
20 BT
Tissue UBE2Q2 hypo methylation, UBE2Q1 hyper methylation. Mokarram [52]
tyrosine kinases and g protein coupled receptors
 VIM, CXCR4, DOK7 2018 Breast 60 patients
40 controls
Blood Hypo methylation. Shirkavand [53]
 GHSR 2019 Gastric 22 N/T Tissue Hyper methylation. Amini [54]
 EDNRB 2017 Colorectal 45 N/T Tissue Hyper methylation. Mousavi Ardehaie [55]
signaling pathways
 APC, DDK3, SFRP2, SFRP4, SFRP5, WIF1, WNT5A 2014 Colorectal 125 N/T Tissue Aberrant methylations. Samaei [56]
 APC 2009 Esophageal 45 N/T Tissue Hyper methylation. Zare [57]
 SFRP2 2016 Colorectal 25 patients
25 controls
Fecal Hyper methylation. Babaei [58]
 PTEN, miR-21 2016 Colorectal 125 N/T Tissue MiR-21 over expression, PTEN under expression. Yazdani [59]
 PTEN 2011 Breast 53 patients
20 controls
Tissue Hyper methylation. Sadeq [60]
 PTEN 2016 Breast 103 patients
102 controls
Blood Hyper methylation. Yari [61]
developmental factors
 ALX4 2015 Colorectal 25 patients
25 controls
Serum Hyper methylation. Salehi [62]
 PAX5 2018 Gastric 35 patients
35 controls
Blood Hyper methylation. Haghverdi [63]
 MiR-129-2 2019 Gastric 50 N/T Tissue Hyper methylation. Alizadeh [64]
nuclear receptors
 ER-a (ER3,4,5) 2012 Breast 60 patients Tissue Hyper methylation. Ramezani [65]
 ER-a 2012 Breast 100 patients Tissue Hyper methylation. Izadi [66]
 ER-a 2012 Breast 49 patients
51 controls
Tissue   Izadi [67]
 RARB, p16 2011 Prostate 42 patients
21 controls
Tissue Hyper methylation. Ameri [68]
apoptosis
 APAF1,CASP8 2018 Gastric 30 patients
30 controls
Blood Hyper methylation. Azarkhazin [69]
 FADD, FAS 2014 Oral 86 patients
68 controls
Tissue FAS promoter hyper methylation. Saberi [70]
 ATM 2015 Brain 30 patients
2 controls
Tissue Hyper methylation. Mehdipour [71]
 CTLA4 2014 Gastric 85 N/T Tissue Hyper methylation. Kordi-Tamandani [72]
  1. a Tumor tissues and normal margins.
  2. b Malignant tumors.
  3. c Benign tumors