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Table 2 CRISPR/Cas9- based cancer mouse models (reviewed in [40])

From: New insights on CRISPR/Cas9-based therapy for breast Cancer

Cancer type Mouse strain Vector Target gene(s) Reference
Lung adenocarcinoma Kraslsl-G12D/+ Lentivirus NKX, PTEN, APC [41]
Lung adenocarcinoma CD1 Adenovirus EML4 [42]
Burkitt lymphoma Arf/− EμMyc Retrovirus p53 [43]
Glioblastoma Crl:CD1 mice Transfection TRP53, PTEN, NF1 [10]
Acute myeloid leukemia C57Bl/6 mice Lentivirus DNMT3A, EZH2, RUNX1 [1]
Burkitt lymphoma Eμ--Myc mice Lentivirus p53 [44]
Pancreatic adenocarcinoma KrasLSL-G12D/+ Lentivirus LKB1 [45]
Lung metastases KrasG12D/+; p53−/− Lentiviral Multiple hits [46]
Tumor regression Foxn1numice Transfection PKCβ A509T [47]