Table 2 Results of the meta-analysis on APOB rs693 polymorphism and gallstone disease risk in total and types of subgroups
Variables | N | Case/Control | Allelic contrast | Heterozygote comparison | Dominant model |
|---|---|---|---|---|---|
OR(95 %CI) PhP I–squared | OR(95 %CI) PhP I–squared | OR(95 %CI) PhP I–squared | |||
Total | 14 | 1583/1794 | 1.40(1.05–1.87)0.000 0.023 73.9 % | 1.58(1.13–2.21)0.000 0.007 67.8 % | 1.54(1.09–2.17)0.000 0.014 71.1 % |
Ethnicity | |||||
Asian | 10 | 1107/1326 | 1.94(1.27–2.95)0.000 0.002 73.7 % | 2.18(1.48–3.21)0.008 0.000 59.3 % | 2.14(1.41–3.24)0.002 0.000 65.8 % |
European | 4 | 476/468 | 0.92(0.77–1.11)0.118 0.382 48.9 % | 0.85(0.64–1.14)0.531 0.285 0.0 % | 0.85(0.64–1.12)0.311 0.243 16.1 % |
China | 8 | 782/936 | 2.68(2.01–3.58)0.997 0.000 0.0& | 2.90(2.15–3.92)0.997 0.000 0.0 % | 2.92(2.16–3.94)0.996 0.000 0.0 % |
Not–China | 6 | 801/858 | 0.91(0.79–1.05)0.307 0.200 16.5 % | 0.94(0.76–1.16)0.617 0.557 0.0 % | 0.90(0.73–1.11)0.540 0.315 0.0 % |
SOC | |||||
HB | 9 | 741/609 | 1.63(1.07–2.49)0.000 0.023 70.0 % | 1.83(1.18–2.84)0.009 0.007 59.1 % | 1.79(1.13–2.84)0.002 0.014 64.9 % |
PB | 5 | 842/1185 | 1.28(0.84–1.94)0.000 0.256 82.9 % | 1.39(0.85–2.25)0.001 0.187 78.3 % | 1.35(0.82–2.23)0.000 0.232 80.5 % |
Sex subgroup | |||||
Male | 3 | 215/441 | 1.62(0.74–3.58)0.031 0.231 71.3 % | 1.65(0.76–3.59)0.067 0.208 62.9 % | 1.67(0.74–3.80)0.046 0.219 67.6 % |
Female | 4 | 345/443 | 1.56(0.80–3.04)0.004 0.192 77.8 % | 1.75(0.79–3.88)0.007 0.167 75.4 % | 1.72(0.77–3.85)0.005 0.188 77.0 % |