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Table 2 Results of the meta-analysis on APOB rs693 polymorphism and gallstone disease risk in total and types of subgroups

From: Association of apolipoprotein B XbaI (rs693) polymorphism and gallstone disease risk based on a comprehensive analysis

Variables

N

Case/Control

Allelic contrast

Heterozygote comparison

Dominant model

OR(95 %CI) PhP I–squared

OR(95 %CI) PhP I–squared

OR(95 %CI) PhP I–squared

Total

14

1583/1794

1.40(1.05–1.87)0.000 0.023 73.9 %

1.58(1.13–2.21)0.000 0.007 67.8 %

1.54(1.09–2.17)0.000 0.014 71.1 %

Ethnicity

     

Asian

10

1107/1326

1.94(1.27–2.95)0.000 0.002 73.7 %

2.18(1.48–3.21)0.008 0.000 59.3 %

2.14(1.41–3.24)0.002 0.000 65.8 %

European

4

476/468

0.92(0.77–1.11)0.118 0.382 48.9 %

0.85(0.64–1.14)0.531 0.285 0.0 %

0.85(0.64–1.12)0.311 0.243 16.1 %

China

8

782/936

2.68(2.01–3.58)0.997 0.000 0.0&

2.90(2.15–3.92)0.997 0.000 0.0 %

2.92(2.16–3.94)0.996 0.000 0.0 %

Not–China

6

801/858

0.91(0.79–1.05)0.307 0.200 16.5 %

0.94(0.76–1.16)0.617 0.557 0.0 %

0.90(0.73–1.11)0.540 0.315 0.0 %

SOC

     

HB

9

741/609

1.63(1.07–2.49)0.000 0.023 70.0 %

1.83(1.18–2.84)0.009 0.007 59.1 %

1.79(1.13–2.84)0.002 0.014 64.9 %

PB

5

842/1185

1.28(0.84–1.94)0.000 0.256 82.9 %

1.39(0.85–2.25)0.001 0.187 78.3 %

1.35(0.82–2.23)0.000 0.232 80.5 %

Sex subgroup

    

Male

3

215/441

1.62(0.74–3.58)0.031 0.231 71.3 %

1.65(0.76–3.59)0.067 0.208 62.9 %

1.67(0.74–3.80)0.046 0.219 67.6 %

Female

4

345/443

1.56(0.80–3.04)0.004 0.192 77.8 %

1.75(0.79–3.88)0.007 0.167 75.4 %

1.72(0.77–3.85)0.005 0.188 77.0 %

  1. Ph: value of Q-test for heterogeneity test; P: Z-test for the statistical significance of the OR