From: MicroRNAs as the critical regulators of cisplatin resistance in gastric tumor cells
Gene | Target | Effect on the target | Effect on the tumor cells | Study | Year |
---|---|---|---|---|---|
Signaling pathways | |||||
Circ-AKT3 | miR-198 | Down regulation | Increased CDDP resistance | Huang [6] | 2019 |
miR-34a | MET | Down regulation | Increased CDDP sensitivity | Zhang [7] | 2016 |
miR-106a | PTEN | Down regulation | Increased CDDP resistance | Fang [15] | 2013 |
miR-21 | PTEN | Down regulation | Increased CDDP resistance | Yang [16] | 2013 |
miR-195 | AKT3 | Down regulation | Increased CDDP sensitivity | Ye [17] | 2017 |
CRAL | miR-505 | Down regulation | Increased CDDP sensitivity | Wang [18] | 2020 |
miR-7 | mTOR | Down regulation | Increased CDDP sensitivity | Xu [19] | 2017 |
miR-375 | ERBB2 | Down regulation | Increased CDDP sensitivity | Zhou [20] | 2016 |
miR-101 | VEGF-C | Down regulation | Increased CDDP sensitivity | Li [21] | 2016 |
miR-362 | CYLD | Down regulation | Increased CDDP resistance | Xia [22] | 2014 |
miR-20a | CYLD | Down regulation | Increased CDDP resistance | Zhu [23] | 2016 |
miR-20a | NFKBIB | Down regulation | Increased CDDP resistance | Du [24] | 2016 |
miR-130a | CCL22 | Down regulation | Increased CDDP sensitivity | Fang [25] | 2020 |
miR-206 | MAPK3 | Down regulation | Increased CDDP sensitivity | Chen [26] | 2019 |
miR-129 | MAPK3 | Down regulation | Increased CDDP sensitivity | Cao [27] | 2019 |
Autophagy and apoptosis | |||||
miR-181a | ATG5 | Down regulation | Increased CDDP sensitivity | Zhao [28] | 2016 |
MALAT1 | miR-30b | Down regulation | Increased CDDP resistance | Xi [29] | 2019 |
miR-218 | BIRC5 | Down regulation | Increased CDDP sensitivity | Zhang [30] | 2018 |
Circ-CCDC66 | miR-618 | Down regulation | Increased CDDP resistance | Zhang [31] | 2020 |
miR-136 | AEG1, BCL2 | Down regulation | Increased CDDP sensitivity | Yu [32] | 2018 |
miR-449a | BCL2, CCND1 | Down regulation | Increased CDDP sensitivity | Hu [33] | 2014 |
miR-143 | IGF1R and BCL2 | Down regulation | Increased CDDP sensitivity | Zhuang [34] | 2015 |
miR-148a-3p | RAB12, AKAP1 | Down regulation | Increased CDDP sensitivity | Li [35] | 2017 |
miR-193a-3p | SRSF2 | Down regulation | Increased CDDP resistance | Lee [36] | 2019 |
Epithelial Mesenchymal Transition (EMT) | |||||
miR-200c | ZEB2 | Down regulation | Increased CDDP sensitivity | Jiang [37] | 2017 |
PCAT-1 | miR-128 | Down regulation | Increased CDDP resistance | Guo [38] | 2019 |
miR-574-3p | ZEB1 | Down regulation | Increased CDDP sensitivity | Wang [39] | 2019 |
miR-30a | SNAI1, VIM | Down regulation | Increased CDDP sensitivity | Wang [40] | 2016 |
miR-17 | DEDD | Down regulation | Increased CDDP resistance | Wu [41] | 2018 |
Drug efflux | |||||
miR-129 | MDR1 | Down regulation | Increased CDDP sensitivity | Lu [42] | 2017 |
miR-30a | MDR1 | Down regulation | Increased CDDP sensitivity | Du [43] | 2018 |
HOTAIR | miR-126 | Down regulation | Increased CDDP resistance | Yan [44] | 2016 |
HOTAIR | miR-34a | Down regulation | Increased CDDP resistance | Cheng [45] | 2018 |
miR-132 | SIRT1 | Down regulation | Increased CDDP resistance | Zhang [46] | 2017 |
Protein kinases | |||||
Let-7b | AURKB | Down regulation | Increased CDDP sensitivity | Han [47] | 2018 |
Hsa-Circ-0081143 | miR-646 | Down regulation | Increased CDDP resistance | Xue [48] | 2019 |
miR-4290 | PDK1 | Down regulation | Increased CDDP sensitivity | Qian [49] | 2020 |
miR-221-5p | DDR1 | Down regulation | Increased CDDP sensitivity | Jiang [50] | 2020 |
Transcription factors | |||||
miR-613 | SOX9 | Down regulation | Increased CDDP sensitivity | Xue [51] | 2019 |
miR-421 | CASP3 and CDH1 | Down regulation | Increased CDDP resistance | Ge [52] | 2016 |
Circ-DONSON | miR-802 | Down regulation | Increased CDDP resistance | Liu [53] | 2020 |
Structural and DNA repair factors | |||||
miR-101 | ANXA2 | Down regulation | Increased CDDP sensitivity | Bao [54] | 2017 |
miR-223 | FBXW7 | Down regulation | Increased CDDP resistance | Zhou [55] | 2015 |
miR-320a | ADAM10 | Down regulation | Increased CDDP sensitivity | Ge [56] | 2017 |
miR-876-3p | TMED3 | Down regulation | Increased CDDP sensitivity | Peng [57] | 2019 |
HOTTIP | miR-218 | Down regulation | Increased CDDP resistance | Wang [58] | 2019 |
miR-138-5p | ERCC1 and ERCC4 | Down regulation | Increased CDDP sensitivity | Ning [59] | 2019 |
Circ-0026359 | miR-1200 | Down regulation | Increased CDDP resistance | Zhang [60] | 2020 |