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Table 1 All of the miRNAs associated with cisplatin (CDDP) resistance in gastric tumor cells

From: MicroRNAs as the critical regulators of cisplatin resistance in gastric tumor cells

Gene Target Effect on the target Effect on the tumor cells Study Year
Signaling pathways
Circ-AKT3 miR-198 Down regulation Increased CDDP resistance Huang [6] 2019
miR-34a MET Down regulation Increased CDDP sensitivity Zhang [7] 2016
miR-106a PTEN Down regulation Increased CDDP resistance Fang [15] 2013
miR-21 PTEN Down regulation Increased CDDP resistance Yang [16] 2013
miR-195 AKT3 Down regulation Increased CDDP sensitivity Ye [17] 2017
CRAL miR-505 Down regulation Increased CDDP sensitivity Wang [18] 2020
miR-7 mTOR Down regulation Increased CDDP sensitivity Xu [19] 2017
miR-375 ERBB2 Down regulation Increased CDDP sensitivity Zhou [20] 2016
miR-101 VEGF-C Down regulation Increased CDDP sensitivity Li [21] 2016
miR-362 CYLD Down regulation Increased CDDP resistance Xia [22] 2014
miR-20a CYLD Down regulation Increased CDDP resistance Zhu [23] 2016
miR-20a NFKBIB Down regulation Increased CDDP resistance Du [24] 2016
miR-130a CCL22 Down regulation Increased CDDP sensitivity Fang [25] 2020
miR-206 MAPK3 Down regulation Increased CDDP sensitivity Chen [26] 2019
miR-129 MAPK3 Down regulation Increased CDDP sensitivity Cao [27] 2019
Autophagy and apoptosis
miR-181a ATG5 Down regulation Increased CDDP sensitivity Zhao [28] 2016
MALAT1 miR-30b Down regulation Increased CDDP resistance Xi [29] 2019
miR-218 BIRC5 Down regulation Increased CDDP sensitivity Zhang [30] 2018
Circ-CCDC66 miR-618 Down regulation Increased CDDP resistance Zhang [31] 2020
miR-136 AEG1, BCL2 Down regulation Increased CDDP sensitivity Yu [32] 2018
miR-449a BCL2, CCND1 Down regulation Increased CDDP sensitivity Hu [33] 2014
miR-143 IGF1R and BCL2 Down regulation Increased CDDP sensitivity Zhuang [34] 2015
miR-148a-3p RAB12, AKAP1 Down regulation Increased CDDP sensitivity Li [35] 2017
miR-193a-3p SRSF2 Down regulation Increased CDDP resistance Lee [36] 2019
Epithelial Mesenchymal Transition (EMT)
miR-200c ZEB2 Down regulation Increased CDDP sensitivity Jiang [37] 2017
PCAT-1 miR-128 Down regulation Increased CDDP resistance Guo [38] 2019
miR-574-3p ZEB1 Down regulation Increased CDDP sensitivity Wang [39] 2019
miR-30a SNAI1, VIM Down regulation Increased CDDP sensitivity Wang [40] 2016
miR-17 DEDD Down regulation Increased CDDP resistance Wu [41] 2018
Drug efflux
miR-129 MDR1 Down regulation Increased CDDP sensitivity Lu [42] 2017
miR-30a MDR1 Down regulation Increased CDDP sensitivity Du [43] 2018
HOTAIR miR-126 Down regulation Increased CDDP resistance Yan [44] 2016
HOTAIR miR-34a Down regulation Increased CDDP resistance Cheng [45] 2018
miR-132 SIRT1 Down regulation Increased CDDP resistance Zhang [46] 2017
Protein kinases
Let-7b AURKB Down regulation Increased CDDP sensitivity Han [47] 2018
Hsa-Circ-0081143 miR-646 Down regulation Increased CDDP resistance Xue [48] 2019
miR-4290 PDK1 Down regulation Increased CDDP sensitivity Qian [49] 2020
miR-221-5p DDR1 Down regulation Increased CDDP sensitivity Jiang [50] 2020
Transcription factors
miR-613 SOX9 Down regulation Increased CDDP sensitivity Xue [51] 2019
miR-421 CASP3 and CDH1 Down regulation Increased CDDP resistance Ge [52] 2016
Circ-DONSON miR-802 Down regulation Increased CDDP resistance Liu [53] 2020
Structural and DNA repair factors
miR-101 ANXA2 Down regulation Increased CDDP sensitivity Bao [54] 2017
miR-223 FBXW7 Down regulation Increased CDDP resistance Zhou [55] 2015
miR-320a ADAM10 Down regulation Increased CDDP sensitivity Ge [56] 2017
miR-876-3p TMED3 Down regulation Increased CDDP sensitivity Peng [57] 2019
HOTTIP miR-218 Down regulation Increased CDDP resistance Wang [58] 2019
miR-138-5p ERCC1 and ERCC4 Down regulation Increased CDDP sensitivity Ning [59] 2019
Circ-0026359 miR-1200 Down regulation Increased CDDP resistance Zhang [60] 2020