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Fig. 1 | Genes and Environment

Fig. 1

From: Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats

Fig. 1

Histological examinations of lung of rats from control and silica-exposed groups at different time points. a HE staining for histopathologic changes in lungs of rats (× 200). a1-a5: Lungs from rats of control group on day 1, 7, 14, 21, 28, respectively; b1: Lungs of rats from silica-exposed group. A few inflammatory cells were found on day 1; b2-b3: Lungs of rats from silica-exposed group on day 7 and 14. Inflammatory cells (red arrow) increased; b4-b5: Lungs of rats from silica-exposed group on day 21 and 28. A large amount of consolidation areas and nodes (circle) formed; b Masson staining for histopathologic changes in lungs of rats (× 200). c1-c5: Lungs of rats from control group at day 1, 7, 14, 21, 28, respectively); d1-d2: Lungs of rats from silica-exposed group on day 1 and 7. There were normal lung tissue with no visible fibrous tissue; d3: Lungs of rats from silica-exposed group on day 14. A few of fibroblast were observed; d4: Lungs of rats from silica-exposed group on day 21. Fibroblast gradually increase and tiny collagen fibers (black arrow) were found; d5: Lungs of rats from silica-exposed group on day 28. Dense deposits of blue collagenous fibers and primary cellular nodules (circle) were observed in the interstitium of the lungs from rats

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