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Table 1 The gpt mutation spectra in the liver of BaP and ENU-treated homozygous gpt delta rats

From: New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

  0 mg/kg/day (28 + 3d) BaP 125 mg/kg/day (28 + 3d) ENU 50 mg/kg/day (5 + 26d)
  male female male female male female
No. % MF (x10− 6) No. % MF (x10− 6) No. % MF (x10− 6) No. % MF (x10− 6) No. % MF (x10− 6) No. % MF (x10− 6)
Base substitution
 Transition
  G:C to A:T 15 40.5 2.2 17 45.9 3.0 5 12.2 6.8 7 16.3 16.2 7 15.6 14.9 9 21.4 18.1
  (at CpG) (6)    (10)    (3)    (1)    (1)    (2)   
  A:T to G:C 4 10.8 0.6 2 5.4 0.3 2 4.9 2.7 0 0.0 0.0 10 22.2 21.3 5 11.9 10.1
 Transversion
  G:C to T:A 6 16.2 0.9 8 21.6 1.4 19 46.3 25.7 15 34.9 34.8 7 15.6 14.9 4 9.5 8.1
  G:C to C:G 0 0.0 0.0 3 8.1 0.5 6 14.6 8.1 9 20.9 20.9 0 0.0 0.0 1 2.4 2.0
  A:T to T:A 0 0.0 0.0 1 2.7 0.2 0 0.0 0.0 2 4.7 4.6 11 24.4 23.4 14 33.3 28.2
  A:T to C:G 1 2.7 0.1 0 0.0 0.0 0 0.0 0.0 2 4.7 4.6 7 15.6 14.9 7 16.7 14.1
Deletion 8 21.6 1.2 5 13.5 0.9 6 14.6 8.1 5 11.6 11.6 3 6.7 6.4 1 2.4 2.0
  1 bp  6    4    3    3    2    1   
  > 2 bps  2    1    3    2    1    0   
Insertion 2 5.4 0.3 0 0.0 0.0 2 4.9 2.7 1 2.3 2.3 0 0.0 0.0 1 2.4 2.0
Others 1 2.7 0.1 1 2.7 0.2 1 2.4 1.4 2 4.7 4.6 0 0.0 0.0 0 0.0 0.0
Total 37 100 5.3 37 100 6.5 41 100 55.4 43 100 99.7 45 100 95.9 42 100 84.7