From: Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
Msh2(+/+) | Msh2(−/−) | |||||||
---|---|---|---|---|---|---|---|---|
0 g/L | 1.5 g/L | 0 g/L | 1.5 g/L | |||||
Type of mutation in gpt | Number | % | Number | % | Number | % | Number | % |
Base substitution | ||||||||
Transition | ||||||||
G:C → A:T | 3 | 30 | 10 | 36 | 51 | 48 | 60 | 40 |
(CpG site) | (1) | (8) | (20) | (35) | ||||
A:T → G:C | 0 | 0 | 2 | 7 | 13 | 12 | 25 | 17 |
Transversion | ||||||||
G:C → T:A | 2 | 20 | 8 | 29 | 10 | 9 | 19 | 13 |
G:C → C:G | 0 | 0 | 1 | 4 | 0 | 0 | 1 | 1 |
A:T → T:A | 0 | 0 | 2 | 7 | 4 | 4 | 2 | 1 |
A:T → C:G | 1 | 10 | 0 | 0 | 6 | 6 | 2 | 1 |
Deletion | ||||||||
1 | 2 | 20 | 2 | 7 | 17 | 16 | *26 | 17 |
≧2 | 1 | 10 | 3 | 11 | 0 | 0 | 0 | 0 |
Insertion | 1 | 10 | 0 | 0 | 6 | 6 | *12 | 8 |
Other | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
Total | 10 | 100 | 28 | 100 | 107 | 100 | 149 | 100 |