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Table 1 Intestinal gpt mutations in Msh2-bearing (Ms2(+/+)) or Msh2-KO (Msh2(-/-)) mice carrying gpt to which potassium bromate in the drinking water at a dose of 0 or 1.5 g/L was administered for 28 days

From: Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

  Msh2(+/+) Msh2(−/−)
0 g/L 1.5 g/L 0 g/L 1.5 g/L
Type of mutation in gpt Number % Number % Number % Number %
Base substitution
Transition
  G:C → A:T 3 30 10 36 51 48 60 40
    (CpG site) (1)   (8)   (20)   (35)  
  A:T → G:C 0 0 2 7 13 12 25 17
Transversion
  G:C → T:A 2 20 8 29 10 9 19 13
  G:C → C:G 0 0 1 4 0 0 1 1
  A:T → T:A 0 0 2 7 4 4 2 1
  A:T → C:G 1 10 0 0 6 6 2 1
Deletion
  1 2 20 2 7 17 16 *26 17
  2 1 10 3 11 0 0 0 0
Insertion 1 10 0 0 6 6 *12 8
Other 0 0 0 0 0 0 2 1
Total 10 100 28 100 107 100 149 100