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Table 1 Intestinal gpt mutations in Msh2-bearing (Ms2(+/+)) or Msh2-KO (Msh2(-/-)) mice carrying gpt to which potassium bromate in the drinking water at a dose of 0 or 1.5 g/L was administered for 28 days

From: Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

 

Msh2(+/+)

Msh2(−/−)

0 g/L

1.5 g/L

0 g/L

1.5 g/L

Type of mutation in gpt

Number

%

Number

%

Number

%

Number

%

Base substitution

Transition

  G:C → A:T

3

30

10

36

51

48

60

40

    (CpG site)

(1)

 

(8)

 

(20)

 

(35)

 

  A:T → G:C

0

0

2

7

13

12

25

17

Transversion

  G:C → T:A

2

20

8

29

10

9

19

13

  G:C → C:G

0

0

1

4

0

0

1

1

  A:T → T:A

0

0

2

7

4

4

2

1

  A:T → C:G

1

10

0

0

6

6

2

1

Deletion

  1

2

20

2

7

17

16

*26

17

  2

1

10

3

11

0

0

0

0

Insertion

1

10

0

0

6

6

*12

8

Other

0

0

0

0

0

0

2

1

Total

10

100

28

100

107

100

149

100