Fig. 17

Staggered arrangements of incoming purine nucleoside triphosphates and 1,N⁶-ε-dAdo in two pol η insertion stage complexes [118]. a active site conformation in the complex with dAMPNPP opposite 1,N⁶-ε-dAdo, viewed into the DNA major groove; b rotated by 90° and viewed perpendicular to the adenine plane. c Active site conformation in the complex with dGMPNPP opposite 1,N⁶-ε-dAdo, viewed into the DNA major groove, and d rotated by 90° and viewed perpendicular to the guanine plane. Selected active site residues are colored by atom with carbon atoms shown in maroon (1,N⁶-ε-dAdo), orange (incoming nucleotide), purple (Arg-61 and Gln-38 from the finger domain), or magenta (Asp/Glu coordinating to Mg²⁺; cyan spheres)