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Fig. 18 | Genes and Environment

Fig. 18

From: Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides

Fig. 18

Close views of active site regions of Dpo4 crystal structures [90]. a Dpo4•DNA•Ca2+ (X = 1,N2-ε-dGuo and Z = T). b Dpo4•DNA•dATP•Ca2+ (X = 1,N2-ε-dGuo and Z = T). c Dpo4–3. Dpo4•DNA•ddATP•low Mg2+ (X = 1,N2-ε-dGuo and Z = T). d Dpo4–4. Dpo4•DNA•Ca2+ (Z = C). The color codes for protein and DNA are: dATP and ddATP are drawn in pink, ddGTP in green, and divalent metal ions are shown as red spheres

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