Fig. 10

Reconstructed mass chromatograms at the MS² scan stage of a human prostate sample targeting dG-C8-PhIP. One subject is shown with dG-C8-PhIP below the detection limit, and a second patient is positive for dG-C8-PhIP. [¹³C₁₀]-dG-C8-PhIP was employed as the internal standard at a level of 3 adducts per 10⁸ nucleotides. The MS³ scan stage product in spectra confirmed the identities of dG-C8-PhIP and its internal standard. Proposed MS³ fragmentation pathways are displayed; isotopically labeled ¹³C atoms of the internal standard are marked in red. Adapted with permission from [214]