Fig. 16
From: Metabolism and biomarkers of heterocyclic aromatic amines in humans
HAA and HONH-HAA cytotoxicity and DNA adduct formation in LNCaP cells. a and b LNCaP cells were treated with DMSO (0.1%), HAAs, and HONH-HAAs (0.1 μM – 10 μM), for 24 h. Cell viability was evaluated by the MTS assay. c and d HAA and HONH-HAA DNA adduct formation in LNCaP cells after 24 h were measured by UPLC-ESI/MS3. Data are representative of at least three different experiment and are expressed as mean ± SD. ND: not detected. Ctrl: control