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Table 2 HAA mutagenicity in rodentsa

From: Metabolism and biomarkers of heterocyclic aromatic amines in humans

HAA Animal Strain Target organ Mutations
H-ras Ki-ras N-ras p53 APC β-Cat MM LacI LacZ
PhIP Rat F344 Colon 0/9 0/9 0/9 0/9 4/8 4/7 7/8   
Big Blue Colon mucosa         227/227  
Mammary gland         149/149  
Mouse CDF1 Lymphoid tissue          
Big Blue Colon mucosa         115/115 40/40
MeIOx Rat F344 Zymbal gland 2/6         
MeIQ Rat F344 Zymbal gland 11/14         
IQ Rat F344 Colon 0/11 0/11 0/11 0/11 2/13 5/5    
Zymbal gland 4/7, 5/9 3/9   4/15      
Mouse CDF1 Liver 7/34         
lung   49/54        
Glu-P-1 Rat F344 Colon 0/7 1/7 0/6 0/7      
  1. areproduced with permission [2, 68]