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Table 2 HAA mutagenicity in rodentsa

From: Metabolism and biomarkers of heterocyclic aromatic amines in humans

HAA

Animal

Strain

Target organ

Mutations

H-ras

Ki-ras

N-ras

p53

APC

β-Cat

MM

LacI

LacZ

PhIP

Rat

F344

Colon

0/9

0/9

0/9

0/9

4/8

4/7

7/8

  

Big Blue

Colon mucosa

       

227/227

 

Mammary gland

       

149/149

 

Mouse

CDF1

Lymphoid tissue

         

Big Blue

Colon mucosa

       

115/115

40/40

MeIOx

Rat

F344

Zymbal gland

2/6

        

MeIQ

Rat

F344

Zymbal gland

11/14

        

IQ

Rat

F344

Colon

0/11

0/11

0/11

0/11

2/13

5/5

   

Zymbal gland

4/7, 5/9

3/9

 

4/15

     

Mouse

CDF1

Liver

7/34

        

lung

 

49/54

       

Glu-P-1

Rat

F344

Colon

0/7

1/7

0/6

0/7

     
  1. areproduced with permission [2, 68]
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Genes and Environment

ISSN: 1880-7062

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