Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta

Table 1 Salmonella typhimurium¹ YG strains

Strain	Description	Reference
TA98	TA1538 (pKM101)	[19, 20]
TA98NR	as TA98 but deficient in classical nitroreductase	[21]
TA98/1,8-DNP₆	as TA98 but deficient in O-acetyltransferase	[21]
TA1538/NR	as TA1538 but deficient in classical nitroreductase	[22]
TA1538/1,8-DNP	as TA1538 but deficient in O-acetyltransferase	[22]
YG1006	TA1538/1,8-DNP (pYG121)²	[16]
YG1012	TA1538/1,8-DNP (pYG213)³	[23]
YG1019	TA1538/1,8-DNP (pYG219)⁴	[23]
YG1020	TA98 (pBR322-AP^s)	[16]
YG1021	TA98 (pYG216)⁵: a nitroreductase-overproducing strain	[24]
YG1024	TA98 (pYG219)⁴: an O-acetyltransferase-overproducing strain	[16]
YG1024NR	TA98NR (pYG219)⁴: as TA98NR (nitroreductase-deficient) but O-acetyltransferase is overexpressed	[25]
YG1041	TA98 (pYG233)^6: a nitroreductase and O-acetyltransferase-overproducing strain	[26]
TA100	TA1535 (pKM101)	[19, 20]
TA100NR	as TA100 but deficient in classical nitroreductase	[21]
TA100/1,8-DNP	as TA100 but deficient in O-acetyltransferase	[21]
YG1025	TA100 (pBR322-AP^s)	[16]
YG1026	TA100 (pYG216)⁵: a nitroreductase-overproducing strain	[24]
YG1029	TA100 (pYG219)⁴: an O-acetyltransferase-overproducing strain	[16]
YG1042	TA100 (pYG233)⁶: a nitroreductase and O-acetyltransferase-overproducing strain	[26]

¹The formal name Salmonella enterica subsp.enterica serovar Typhimurium is abbreviated as Salmonella typhimurium in Tables, Figures and the text
²Plasmid pYG121 is a derivative of plasmid pBR322 having part of the chromosome of TA1538 including the oat gene encoding O-acetyltransferase
³Plasmid pYG213 is a deletion derivative of pYG122. Plasmid pYG121, 122, 213 have the ampicillin-resistance gene
⁴Plasmid pYG219 is a derivative of pBR322 having 1.35 kb DNA containing the oat gene from pYG213. It has the tetracycline-resistance gene
⁵Plasmid pYG216 is a derivative of pBR322 having 6.85 kb DNA containing the cnr gene encoding the classical nitroreductase from strain TA1538. Plasmid pYG216 has the tetracycline-resistance gene
⁶Plasmid pYG233 is a derivative of pBR322 having the oat and cnr genes. Plasmid pYG233 has the tetracycline-resistance gene

ISSN: 1880-7062