MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Genes and Environment

Table 2 Pooled ORs and 95%CIs of the association between MTHFR A1298C polymorphism and stroke

Total and subgroups	Studies	CC + CA vs AA				CC vs CA + AA				C VS A
Total and subgroups	Studies	OR	95%CI	I²	P	OR	95%CI	I²	P	OR	95%CI	I²	P
Total	40	1.19	1.06 ~ 1.33	51.8%	< 0.001	1.43	1.15 ~ 1.77	40.6%	0.006	1.19	1.07 ~ 1.32	61.1%	< 0.001
Ethnicity
Asian	22	1.28	1.17 ~ 1.47	40.9%	0.025	1.84	1.49 ~ 2.27	0.0%	0.057	1.29	1.16 ~ 1.44	36.8%	0.044
Caussian	16	0.99	0.85–1.17	29.2%	0.131	1.10	0.81 ~ 1.50	44.0%	0.031	1.01	0.88 ~ 1.16	48.0%	0.017
African	2	2.38	0.43–13.19	91.6%	0.001	3.31	0.04 ~ 276.07	87.8%	0.004	2.63	0.33 ~ 20.97	95.2%	< 0.001
Population
Child	9	1.20	0.85 ~ 1.69	58.9%	0.013	1.25	0.79 ~ 2.00	29.0%	0.187	1.15	0.86 ~ 1.54	66.1%	0..003
Adult	31	1.19	1.06 ~ 1.34	51.1%	0.001	1.48	1.16 ~ 1.89	45.0%	0.005	1.18	1.07 ~ 1.32	60.9%	< 0.001
Stroke type
IS	32	1.24	1.09 ~ 1.42	56.6%	< 0.001	1.38	1.12 ~ 1.69	28.4%	0.076	1.22	1.09 ~ 1.37	63.0%	< 0.001
HS	4	0.89	0.67 ~ 1.18	0.0%	0.811	0.79	0.23 ~ 2.65	64.5%	0.037	0.88	0.70 ~ 1.10	0.0%	0.494
MIXED	4	1.09	0.77 ~ 1.56	36.8%	0.191	2.39	1.09 ~ 5.22	55.9%	0.078	1.27	0.91 ~ 1.78	60.2%	0.057
Source of control
HB	21	1.23	1.06 ~ 1.44	51.4%	0.011	1.54	1.28 ~ 1.86	40.9%	0.033	1.24	1.08 ~ 1.42	60.7%	< 0.001
PB	4	0.88	0.47 ~ 1.62	52.7%	0.003	0.61	0.33 ~ 1.11	39.5%	0.175	0.86	0.49 ~ 1.50	68.8%	0.022
NR	15	1.19	0.98 ~ 1.44	57.9%	0.068	1.38	1.12 ~ 1.70	37.4%	0.071	1.18	1.01 ~ 1.39	59.2%	0.002
Case size
< 100	21	1.28	1.00 ~ 1.65	61.3%	< 0.001	1.36	0.92 ~ 2.01	36.9%	0.050	1.25	1.00 ~ 1.57	69.8%	< 0.001
≥100	19	1.14	1.02 ~ 1.28	36.8%	0.055	1.46	1.12 ~ 1.88	47.5%	0.013	1.16	1.05 ~ 1.28	46.8%	0.013

ISSN: 1880-7062