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Table 2 Pooled ORs and 95%CIs of the association between MTHFR A1298C polymorphism and stroke

From: MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Total and subgroups Studies CC + CA vs AA CC vs CA + AA C VS A
OR 95%CI I2 P OR 95%CI I2 P OR 95%CI I2 P
Total 40 1.19 1.06 ~ 1.33 51.8% < 0.001 1.43 1.15 ~ 1.77 40.6% 0.006 1.19 1.07 ~ 1.32 61.1% < 0.001
Ethnicity              
 Asian 22 1.28 1.17 ~ 1.47 40.9% 0.025 1.84 1.49 ~ 2.27 0.0% 0.057 1.29 1.16 ~ 1.44 36.8% 0.044
 Caussian 16 0.99 0.85–1.17 29.2% 0.131 1.10 0.81 ~ 1.50 44.0% 0.031 1.01 0.88 ~ 1.16 48.0% 0.017
 African 2 2.38 0.43–13.19 91.6% 0.001 3.31 0.04 ~ 276.07 87.8% 0.004 2.63 0.33 ~ 20.97 95.2% < 0.001
Population              
 Child 9 1.20 0.85 ~ 1.69 58.9% 0.013 1.25 0.79 ~ 2.00 29.0% 0.187 1.15 0.86 ~ 1.54 66.1% 0..003
 Adult 31 1.19 1.06 ~ 1.34 51.1% 0.001 1.48 1.16 ~ 1.89 45.0% 0.005 1.18 1.07 ~ 1.32 60.9% < 0.001
Stroke type              
 IS 32 1.24 1.09 ~ 1.42 56.6% < 0.001 1.38 1.12 ~ 1.69 28.4% 0.076 1.22 1.09 ~ 1.37 63.0% < 0.001
 HS 4 0.89 0.67 ~ 1.18 0.0% 0.811 0.79 0.23 ~ 2.65 64.5% 0.037 0.88 0.70 ~ 1.10 0.0% 0.494
 MIXED 4 1.09 0.77 ~ 1.56 36.8% 0.191 2.39 1.09 ~ 5.22 55.9% 0.078 1.27 0.91 ~ 1.78 60.2% 0.057
Source of control              
 HB 21 1.23 1.06 ~ 1.44 51.4% 0.011 1.54 1.28 ~ 1.86 40.9% 0.033 1.24 1.08 ~ 1.42 60.7% < 0.001
 PB 4 0.88 0.47 ~ 1.62 52.7% 0.003 0.61 0.33 ~ 1.11 39.5% 0.175 0.86 0.49 ~ 1.50 68.8% 0.022
 NR 15 1.19 0.98 ~ 1.44 57.9% 0.068 1.38 1.12 ~ 1.70 37.4% 0.071 1.18 1.01 ~ 1.39 59.2% 0.002
Case size              
 < 100 21 1.28 1.00 ~ 1.65 61.3% < 0.001 1.36 0.92 ~ 2.01 36.9% 0.050 1.25 1.00 ~ 1.57 69.8% < 0.001
 ≥100 19 1.14 1.02 ~ 1.28 36.8% 0.055 1.46 1.12 ~ 1.88 47.5% 0.013 1.16 1.05 ~ 1.28 46.8% 0.013