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Fig. 4 | Genes and Environment

Fig. 4

From: PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40

Fig. 4

PRDX1 depletion does not induce chromosomal instability. A Sister chromatid exchange (SCE). PRDX1-depleted cells were cultured in 1 μg/ml Dox for 96 h and SCE in macrochromosomes was assessed. Numbers represent the means and standard deviations of scores from 100 metaphase cells. B Chromosome aberrations. A chromosome analysis was performed with PRDX1-depleted cells. C Chromosome aberrations. A chromosome analysis of was performed with SOD1-depleated cells. SOD1-depleated cells were cultured with or without 1 μg/ml Dox for 96 h and /or ascorbic acid (APM) 200 μM for 96 h. Increase of chromosome aberrations in SOD1-depleated cells was suppressed by APM. The number of chromosome aberrations per 50 metaphase nuclei from the indicated cells was counted. All data represent the mean ± standard deviation from three independent experiments. Asterisks (*) indicate p < 0.05 by a multiple-comparison one-way ANOVA (Tukey’s test), and N.S. indicates not significant (p ≥ 0.05)

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