Skip to main content

Table 1 De novo germline MFs detected by WGS in the offspring of ENU-treated male mice

From: Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring

Offspring ID   Father ID Mother ID No. of bases sequenced No. of mutations De novo MF
(×10− 8/base)
Average   SD  
Control
 501 male 43 50 759,410,873 10 1.3     
 502 male 43 50 765,916,678 14 1.8     
 503 female 43 50 878,853,903 23 2.6     
 504 female 43 50 824,878,986 29 3.5 2.3 ± 1.0  
ENU (10 mg/kg × 2)
 523 male 29 52 884,658,265 45 5.1     
 524 male 29 52 888,192,187 48 5.4     
 528 female 29 52 849,121,370 55 6.5     
 529 female 29 52 924,310,341 248 26.8 10.9 ± 10.6  
        (S529 is excluded.)  
        5.7 ± 0.7 *
  1. * P < 0.01, t-test