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Table 1 De novo germline MFs detected by WGS in the offspring of ENU-treated male mice

From: Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring

Offspring ID

 

Father ID

Mother ID

No. of bases sequenced

No. of mutations

De novo MF

(×10− 8/base)

Average

 

SD

 

Control

 501

male

43

50

759,410,873

10

1.3

    

 502

male

43

50

765,916,678

14

1.8

    

 503

female

43

50

878,853,903

23

2.6

    

 504

female

43

50

824,878,986

29

3.5

2.3

±

1.0

 

ENU (10 mg/kg × 2)

 523

male

29

52

884,658,265

45

5.1

    

 524

male

29

52

888,192,187

48

5.4

    

 528

female

29

52

849,121,370

55

6.5

    

 529

female

29

52

924,310,341

248

26.8

10.9

±

10.6

 
       

(S529 is excluded.)

 
       

5.7

±

0.7

*

  1. * P < 0.01, t-test