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Table 3 Chromosomal damage between genotypes of MTHFR in BD-exposed workers

From: Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

Gene N MN(‰) NPB(‰) NBUD(‰) NDI
MTHFR C677T
CC 11 7.73 ± 4.38 2.73 ± 3.61 2.00 ± 2.00* 2.22 ± 0.11
 CT 23 7.61 ± 3.29 2.96 ± 2.84 2.87 ± 1.98* 2.22 ± 0.12
 TT 9 8.89 ± 4.62 1.56 ± 1.33 5.33 ± 2.60 2.13 ± 0.12
MTHFR A1298C
 AA 28 8.21 ± 3.91 2.07 ± 2.80 3.21 ± 2.50 2.19 ± 0.14
 AC 14 7.50 ± 3.78 3.64 ± 2.76 3.07 ± 2.20 2.22 ± 0.11
 CC 1 5 3 3 2.13
 AC/CC 15 7.33 ± 3.70 3.60 ± 2.67 3.07 ± 2.12 2.21 ± 0.14
  1. NDI nuclear division index
  2. *As seen in Table 4, compared in the BD-exposed group, P < 0.01