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Table 4 Multivariate poisson regression analysis for association between genetic polymorphism (MTHFR) and chromosomal damage in BD-exposed workers

From: Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

Name

Î’

95%CI

X2

P

FR

  

low

Upper

   

Intercept

1.6065

0.8771

2.3360

18.63

<.0001

 

Gender (female)

0.3131

−0.2650

0.8911

1.13

0.2884

1.37 (0.77–2.44)

Age(≤40)

0.1725

−0.3341

0.6790

0.45

0.5046

1.19 (0.72–1.97)

OL(≤20)

−0.2213

−0.7090

0.2663

0.79

0.3736

0.80 (0.49–1.31)

Smoking (no)

−0.1197

− 0.6219

0.3826

0.22

0.6405

0.89 (0.54–1.47)

Drinking (no)

−0.2699

− 0.7513

0.2116

1.21

0.2720

0.76 (0.47–1.24)

MTHFR677(CC)

−1.0185

−1.6335

−0.4036

10.54

0.0012

0.36 (0.20–0.67)*

MTHFR677(CT)

−0.7055

−1.1513

−0.2597

9.62

0.0019

0.49 (0.32–0.77)*

MTHFR1298(AC/CC)

0.2778

−0.1801

0.7357

1.41

0.2344

1.32 (0.84–2.09)

  1. *Compared in BD-exposed group, MTHFR 677 TT genotype as reference, P < 0.05. OL: Occupational Longevity