Genes and Environment

Table 5 Effects of DEB exposure and 5-MTHF addition on chromosomal damage in TK-6 cells

From: Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

		5-MTHF (nmol/L)			One-way ANOVA P	Two-way ANOVA P interaction
CBMN markers	DEB (μmol/L)	3	30	300	One-way ANOVA P	Two-way ANOVA P interaction
MN(‰)	0	7.00 ± 1.00	7.33 ± 1.528	4.00 ± 2.646	0.129
	10	21.67 ± 1.16^aa	13.67 ± 2.31^**	12.33 ± 1.16^***aa	0.001
	20	31.00 ± 1.00^aaabb	25.00 ± 1.00^*aaabb	20.67 ± 4.51^**aaabb	0.010
	40	59.33 ± 3.79^aabc	35.67 ± 7.02^**aaabbbcc	29.33 ± 1.53^***aaabbbcc	< 0.001
	One-way ANOVA P	< 0.001	< 0.001	< 0.001		< 0.001
NPB(‰)	0	4.00 ± 1.00	3.00 ± 1.00	1.33 ± 0.58^*	0.027
	10	6.00 ± 1.00	5.33 ± 2.08	2.66 ± 1.53^*	0.092
	20	12.67 ± 1.53^aaabb	9.33 ± 1.53^*aab	7.33 ± 1.53^**aabb	0.014
	40	25.00 ± 2.65^aaabbbccc	17.33 ± 1.53^**aaabbbccc	12.00 ± 1.73^***#aaabbbcc	< 0.001
	One-way ANOVA P	< 0.001	< 0.001	< 0.001		< 0.001
NBUD(‰)	0	8.00 ± 1.00	6.67 ± 1.16	3.67 ± 0.58^**##	0.004
	10	11.00 ± 1.00^a	10.67 ± 2.08	7.33 ± 1.53^*#aa	0.056
	20	13.33 ± 1.53^aa	12.00 ± 2.646^a	12.00 ± 1.00^aaabb	0.621
	40	27.33 ± 1.53^aaabbbccc	20.67 ± 2.52^**aaabbbcc	15.67 ± 1.16^***#aaabbbcc	< 0.001
	One-way ANOVA P	< 0.001	< 0.001	< 0.001		< 0.001

ANOVA, compared with 5-MTHF 3 nmol/L,*p < 0.05, **p < 0.01, ***p < 0.001; compared with 5-MTHF 30 nmol/L,#p < 0.05, ##p < 0.01, ###p < 0.001. Compared with DEB control (0 μmol/L), a, p < 0.05, aa, p < 0.01, aaa, p < 0.001; compared with DEB 10 μmol/L, b, p < 0.05, bb, p < 0.01, bbb, p < 0.001; compared with DEB 20 μmol/L, c, p < 0.05, cc, p < 0.01, ccc, p < 0.001

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ISSN: 1880-7062

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