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Table 5 Effects of DEB exposure and 5-MTHF addition on chromosomal damage in TK-6 cells

From: Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

  5-MTHF (nmol/L) One-way ANOVA P Two-way ANOVA P interaction
CBMN markers DEB (μmol/L) 3 30 300
MN(‰) 0 7.00 ± 1.00 7.33 ± 1.528 4.00 ± 2.646 0.129  
10 21.67 ± 1.16aa 13.67 ± 2.31** 12.33 ± 1.16***aa 0.001  
20 31.00 ± 1.00aaabb 25.00 ± 1.00*aaabb 20.67 ± 4.51**aaabb 0.010  
40 59.33 ± 3.79aabc 35.67 ± 7.02**aaabbbcc 29.33 ± 1.53***aaabbbcc < 0.001  
One-way ANOVA P < 0.001 < 0.001 < 0.001   < 0.001
NPB(‰) 0 4.00 ± 1.00 3.00 ± 1.00 1.33 ± 0.58* 0.027  
10 6.00 ± 1.00 5.33 ± 2.08 2.66 ± 1.53* 0.092  
20 12.67 ± 1.53aaabb 9.33 ± 1.53*aab 7.33 ± 1.53**aabb 0.014  
40 25.00 ± 2.65aaabbbccc 17.33 ± 1.53**aaabbbccc 12.00 ± 1.73***#aaabbbcc < 0.001  
One-way ANOVA P < 0.001 < 0.001 < 0.001   < 0.001
NBUD(‰) 0 8.00 ± 1.00 6.67 ± 1.16 3.67 ± 0.58**## 0.004  
10 11.00 ± 1.00a 10.67 ± 2.08 7.33 ± 1.53*#aa 0.056  
20 13.33 ± 1.53aa 12.00 ± 2.646a 12.00 ± 1.00aaabb 0.621  
40 27.33 ± 1.53aaabbbccc 20.67 ± 2.52**aaabbbcc 15.67 ± 1.16***#aaabbbcc < 0.001  
One-way ANOVA P < 0.001 < 0.001 < 0.001   < 0.001
  1. ANOVA, compared with 5-MTHF 3 nmol/L,*p < 0.05, **p < 0.01, ***p < 0.001; compared with 5-MTHF 30 nmol/L,#p < 0.05, ##p < 0.01, ###p < 0.001. Compared with DEB control (0 μmol/L), a, p < 0.05, aa, p < 0.01, aaa, p < 0.001; compared with DEB 10 μmol/L, b, p < 0.05, bb, p < 0.01, bbb, p < 0.001; compared with DEB 20 μmol/L, c, p < 0.05, cc, p < 0.01, ccc, p < 0.001
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Genes and Environment

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