Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis

Genes and Environment

Table 2 Pooled ORs and 95 % CIs of the association between ADIPOQ rs2241766 polymorphism and breast cancer

Total and subgroups	Studies	TT vs. TG + GG			TT +TG vs. GG			T vs. G
Total and subgroups	Studies	OR (95 %CI)	P values for OR	I²	OR (95 %CI)	P values for OR	I²	OR (95 %CI)	P values for OR	I²
Total	8	1.2 (0.77-1.89)	0.417	84.20 % ^*	1.05 (0.71-1.56)	0.805	16.00 %	1.17 (0.79-1.74)	0.437	84.30 % ^*
Ethnicity
Asian	3	1.48 (1.08-2.05)	0.016	0.00 %	1.26 (0.61-2.59)	0.551	0.00 %	1.36 (1.04-1.78)	0.024	0.00 %
Non-Asian	5	0.83 (0.70-0.99)	0.040	88.00 % ^*	0.97 (0.61-1.56)	0.913	36.10 %	1.04 (0.57-1.87)	0.907	88.70 % ^*
Source of control
HB	5	1.06 (0.58-1.95)	0.085	89.10 % ^*	1.00 (0.65-1.54)	0.997	33.30 %	1.06 (0.60-1.84)	0.849	89.50 % ^*
PB	3	1.49 (1.01-2.18)	0.041	0.00 %	1.37 (0.50-3.77)	0.539	0.00 %	1.36 (0.99-1.88)	0.056	0.00 %
Case size
<100	4	1.08 (0.78-1.50)	0.655	74.00 % ^*	0.95 (0.39-2.31)	0.912	19.10 %	1.04 (0.57-1.88)	0.907	74.70 %
>100	4	0.92 (0.77-1.09)	0.329	90.50 % ^*	1.08 (0.69-1.68)	0.740	37.30 %	1.31 (0.72-2.37)	0.378	90.60 % ^*
Control size
<100	3	1.67 (1.01-2.77)	0.046	0.00 % ^*	0.98 (0.64-1.49)	0.347	20.10 %	1.52 (1.00-2.30)	0.047	0.00 %
>100	5	0.90 (0.77-1.05)	0.183	86.90 % ^*	1.74 (0.55-5.50)	0.922	0.00 %	1.07 (0.67-1.72)	0.770	87.20 % ^*

HB Hospital-based, PB population-based, ORs odds ratios, CIs confidence interval; * p values for I² less than 0.05

ISSN: 1880-7062