Table 1 Liver MN assay results in the collaborative study by CSGMT/JEMS MMS and rat carcinogenicity data for the test chemicals

2 weeks

Ref.

4 weeks

Ref.

Liver

Other sites

Ref.

Group A

Dimethylnitrosamine

DMN

62–75-9

+

[2]

+

[2]

+

kid, lun, vsc, tes

[22]

N-Nitrosopyrrolidine

NPYR

930–55-2

+

[2]

+

[2]

+

kid, vsc, tes

[22, 23]

4,4′-Methylenedianiline

MDA

101–77-9

+

[2]

+

[2]

+

thy

[24]

N-Nitrosodipropylamine

NDPA

621–64-7

+

[2]

ND

+

eso, nas

[22]

2,4-Dinitrotoluene

2,4-DNT

121–14-2

+

[2]

+

[2]

+

ski, mgl

[22]

2,6-Dinitrotoluene

2,6-DNT

606–20-2

+

[2]

+

[2]

+

–

[22]

Quinoline

QUN

91–22-5

+

[2]

+

[2]

+

–

[25]

p-Dimethylaminoazobenzene

DAB

60–11-7

+

[2]

+

[2]

+

–

[22]

2-Nitropropane

2-NP

79–46-9

+

[2]

+

[2]

+

–

[26]

Monocrotaline

MCT

315–22-0

+

[2]

+

[2]

+

–

[22]

N-Nitrosomorpholine

NMOR

59–89-2

+

[2]

ND

+

vsc

[22]

2-Acetylaminofluorene

2-AAF

53–96-3

+

[2]

+

[2]

+

ski, mgl

[22]

Sudan I (C.I.solvent yellow 14)

Sudan I

842–07-9

+

[21]

ND

+

–

[22]

Thioacetamide

TAA

62–55-5

+

[21]

+

[21]

+

–

[22]

Group B

Mitomycin C

MMC

50–07-7

+

[2]

+

[2]

–

per

[22]

Cyclophosphamide H2O

CP

6055-19-2

–

[2]

ND

–

ub, lym, ner

[27]

Potassium bromate

KBrO3

7758-01-2

–

[2]

–

[2]

–

kid, per, thy

[22]

N-Methyl-N′-nitro-N-nitrosoguanidine

MNNG

70–25-7

–

[2]

–

[2]

–

eso, smi, sto

[22]

Methyl methanesulfonate

MMS

66–27-3

+

[2]

–

[2]

–

hmo, lun, ner

[22, 26]

Kojic acid

KA

501–30-4

–

[2]

–

[2]

–

thy (mouse)

[22]