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Fig. 3 | Genes and Environment

Fig. 3

From: Reactions of 3′,5′-di-O-acetyl-2′-deoxyguansoine and 3′,5′-di-O-acetyl-2′-deoxyadenosine to UV light in the presence of uric acid

Fig. 3

Uric acid dose-dependence and time-course of the concentration changes of AcdGuo reaction products. Uric acid dose-dependence of the concentration changes of (a) each product and (b) AcdGuo and total products, when a solution of 100 μM AcdGuo with 0–400 μM uric acid was irradiated with UV light through a 300-nm longpass filter for 10 min at pH 7.4 and 37 °C. Time-course of the concentration changes of (c) each product and (d) AcdGuo and total products, when a solution of 100 μM AcdGuo with 400 μM uric acid was irradiated with UV light through a 300-nm longpass filter for 0–30 min at pH 7.4 and 37 °C. AcdSph (1 and 2) (closed circle), AcdOz (3) (closed square), AcdIz (4) (closed rhombus), AcdIaox (5) (open circle), 8-oxo-AcdGuo (6) (open square), AcdGuo (closed triangle), and the total concentration of Products 16 (open triangle). All reaction mixtures were analyzed by RP-HPLC. Means ± standard deviation (S.D.) (n = 3) are presented

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