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Fig. 5 | Genes and Environment

Fig. 5

From: o-Aminoazotoluene, 7,12-dimethylbenz[a]anthracene, and N-ethyl-N-nitrosourea, which are mutagenic but not carcinogenic in the colon, rapidly induce colonic tumors in mice with dextran sulfate sodium-induced colitis

Fig. 5

Histopathology results of H&E staining (A, B, D, E, G and H) and β-catenin-immunostaining (C, F, and I) of colonic adenocarcinomas induced by AAT/DSS, DMBA/DSS or ENU/DSS. Figs. B, E and H are enlarged magnifications of those in A, D and G, respectively (the areas surrounded by the yellow frames). Immunohistochemical analysis of β-catenin was performed on serial sections used for H & E staining. The inserts are figures in enlarged magnification. Figs. J and K show the results of H & E staining and β-catenin-immunostaining, respectively, of normal colonic epithelial cells. Yellow bar: 100 μm

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Genes and Environment

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