Fig. 1

Changes in body weight of different treatment groups: COL (A), VBS (B), and DOC (C). The data are expressed as the mean ± SD. ○: Negative (vehicle) control group, ■: low-dose group (4 mg/kg/day (A), 0.125 mg/kg/day (B), 1 mg/kg/day (C)), ▲: middle-dose group (8 mg/kg/day (A), 0.25 mg/kg/day (B), 2 mg/kg/day (C)), ♦: high-dose group (16 mg/kg/day (A), 0.5 mg/kg/day (B), 4 mg/kg/day (C)). Statistical significance: *p < 0.05, **p < 0.01 (Dunnett’s test) compared to the negative control