Table 1 Chemical information
Chemicals | Abbreviation | CAS No. | Source | Lot No. | Purity | Vehicle | Dosage (mg/10 mL/ kg body weight/day) | Route |
|---|---|---|---|---|---|---|---|---|
Aneugens | ||||||||
 Colchicine | COL | 64-86-8 | FUJIFILM Wako Pure Chemical | CTP2407 | > 95% | DW | 4, 8, 16 | po |
 Vinblastine sulfate  (Exal® for Inj. 10 mg) | VBS | 143-67-9 | Nippon Kayaku | Y30400 | (PF) | Saline | 0.125, 0.25, 0.5 | iv |
 Docetaxel hydrate  (TAXOTERE® 20 mg for I.V. Infusion) | DOC | 148408-66-6 | Sanofi | 4D023J | (PF) | Saline | 1, 2, 4 b) | iv |
Non-genotoxic non-carcinogens | ||||||||
 Sodium chloride | NaCl | 7647-14-5 | FUJIFILM Wako Pure Chemical | KPH4443 | ≥99.5% | DW | 500, 1000, 2000 | po |
 Sucrose | SUC | 57-50-1 | Tokyo Chemical Industry | E3PLM | > 99% | DW | 1000, 5000, 10000 | po |
Positive control (clastogens) | ||||||||
 1,2-Dimethylhydrazine dihydrochloride | DMH | 306-37-6 | Tokyo Chemical Industry | VU5VG-RD | 100% | DW | 90 | po |
 N-Nitroso-N-methylurea | MNU | 684-93-5 | Sigma-Aldrich | 100 M1436 | 45% a) | DW | 20 c) | po |
 Mitomycin C  (MITOMYCIN Injection 2 mg) | MMC | 50-07-7 | Kyowa Hakko Kirin | 569ACH | (PF) | Saline | 1 | iv |