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Table 3 Histopathological findings in the rabbit cornea at 24 h after administration

From: Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds

Findings Compounds
Saline 1% EtBr 3% MMS 1% 4-NQO
No. of corneas examined 1 1 1 1
Degeneration/necrosis, corneal epithelium ++
Infiltrate, inflammatory cell, corneal limbus ± ±
Infiltrate, inflammatory cell, corneal stroma ±
  1. −: No abnormal findings, ±: minimal, ++: moderate
  2. EtBr ethidium bromide, MMS methyl methanesulfonate, 4-NQO 4-nitroquinoline 1-oxide