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Table 4 Change in viability of human epithelial cells treated with genotoxic compounds

From: Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds

Incubation time after removing the compoundsa Cell viability (%)
0.5% EtBr 0.5% MMS 0.001% 4-NQO
Non-treated 100.0 ± 2.8 100.0 ± 2.6 100.0 ± 1.5
2 h 89.3 ± 6.1b 115.1 ± 5.1 139.2 ± 2.0
4 h 74.7 ± 8.0b 108.1 ± 0.3 114.2 ± 14.5
6 h 73.1 ± 4.6b 108.2 ± 4.9 122.7 ± 24.2
24 h 39.1 ± 1.3b 108.5 ± 11.3 118.3 ± 13.9
  1. Data are presented as the mean ± SD (n = 3)
  2. EtBr Ethidium bromide, MMS Methyl methanesulfonate, 4-NQO 4-nitroquinoline 1-oxide
  3. aTime of incubation with fresh culture medium after a 1 min exposure to each compound
  4. bSignificantly lower than the non-treated group at 5% probability level (Dunnett’s multiple comparison test, one-tailed)