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Table 1 Frequency of EGFR mutation as reported by clinical features in the general patients

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

 

Sum total

Positive

Negative

P

N

%

N

%

Age

     

0.070

 < 65

672

327

48.66%

345

51.34%

 

65–75

166

74

44.58%

92

55.42%

 

 > 75

26

7

26.92%

19

73.08%

 

Gender

     

0.000

Male

406

150

36.95%

256

63.05%

 

Female

458

258

56.33%

200

43.67%

 

Smoking history

     

0.000

Yes

203

64

31.53%

139

68.47%

 

No

661

344

52.04%

317

47.96%

 

Family history of malignant tumors

     

0.206

Yes

157

69

43.95%

88

56.05%

 

No

707

339

47.95%

368

52.05%

 

Histological and pathological type

     

0.000

AD

757

376

49.67%

381

50.33%

 

SCC

29

5

17.24%

24

82.76%

 

ADSC

3

3

100.00%

0

0.00%

 

LCC

5

1

20.00%

4

80.00%

 

NSCLC

70

23

32.86%

47

67.14%

 

Tumor site

     

0.356

Left

326

158

48.47%

168

51.53%

 

Right

514

242

47.08%

272

52.92%

 

Bilateral

24

8

33.33%

16

66.67%

 

Regional distribution

     

0.092

Central

230

125

54.35%

105

45.65%

 

East

254

103

40.55%

151

59.45%

 

Northeast

207

91

43.96%

116

56.04%

 

Southeast

11

7

63.64%

4

36.36%

 

South

14

6

42.86%

8

57.14%

 

West

26

11

42.31%

15

57.69%

 

Northwest

8

5

62.50%

3

37.50%

 

Southwest

16

7

43.75%

9

56.25%

 

North

65

37

56.92%

28

43.08%

 

Other

34

16

48.48%

17

51.52%

 

Ethnic group

     

0.552

Han

859

406

47.26%

453

52.74%

 

Yi

5

2

40.00%

3

60.00%

 

TNM staging

     

0.198

Ia

206

93

45.15%

113

54.85%

 

Ib

177

85

48.02%

92

51.98%

 

IIa

139

65

46.76%

74

53.24%

 

IIb

97

54

55.67%

43

44.33%

 

IIIa

37

21

56.76%

16

43.24%

 

IIIb

41

13

31.71%

28

68.29%

 

IV

167

77

46.11%

90

53.89%

 

Brain metastasis

     

0.000

Yes

180

60

33.33%

120

66.67%

 

No

684

348

50.88%

336

49.12%

 

Specimen type

     

0.000

Tissue

676

361

53.40%

315

46.60%

 

Plasma

180

42

23.33%

138

76.67%

 

Cytology

8

5

62.50%

3

37.50%

 

Coal producing area

     

0.043

Yes

522

232

44.44%

290

55.56%

 

No

342

176

51.46%

166

48.54%

 

Fuyuan County origin

     

0.007

Yes

254

103

40.55%

151

59.45%

 

No

610

305

50.00%

305

50.00%

 

Xuanwei County origin

     

0.088

Yes

190

81

42.63%

109

57.37%

 

No

674

327

48.52%

347

51.48%

 

Total

864

408

47.22%

456

52.78%

 
  1. AD adenocarcinoma, SCC squamous-cell carcinoma, ADSC adenosquamous carcinoma, LCC large cell carcinoma, NSCLC non-small-cell lung cancer