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Table 1 Frequency of EGFR mutation as reported by clinical features in the general patients

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

  Sum total Positive Negative P
N % N %
Age       0.070
 < 65 672 327 48.66% 345 51.34%  
65–75 166 74 44.58% 92 55.42%  
 > 75 26 7 26.92% 19 73.08%  
Gender       0.000
Male 406 150 36.95% 256 63.05%  
Female 458 258 56.33% 200 43.67%  
Smoking history       0.000
Yes 203 64 31.53% 139 68.47%  
No 661 344 52.04% 317 47.96%  
Family history of malignant tumors       0.206
Yes 157 69 43.95% 88 56.05%  
No 707 339 47.95% 368 52.05%  
Histological and pathological type       0.000
AD 757 376 49.67% 381 50.33%  
SCC 29 5 17.24% 24 82.76%  
ADSC 3 3 100.00% 0 0.00%  
LCC 5 1 20.00% 4 80.00%  
NSCLC 70 23 32.86% 47 67.14%  
Tumor site       0.356
Left 326 158 48.47% 168 51.53%  
Right 514 242 47.08% 272 52.92%  
Bilateral 24 8 33.33% 16 66.67%  
Regional distribution       0.092
Central 230 125 54.35% 105 45.65%  
East 254 103 40.55% 151 59.45%  
Northeast 207 91 43.96% 116 56.04%  
Southeast 11 7 63.64% 4 36.36%  
South 14 6 42.86% 8 57.14%  
West 26 11 42.31% 15 57.69%  
Northwest 8 5 62.50% 3 37.50%  
Southwest 16 7 43.75% 9 56.25%  
North 65 37 56.92% 28 43.08%  
Other 34 16 48.48% 17 51.52%  
Ethnic group       0.552
Han 859 406 47.26% 453 52.74%  
Yi 5 2 40.00% 3 60.00%  
TNM staging       0.198
Ia 206 93 45.15% 113 54.85%  
Ib 177 85 48.02% 92 51.98%  
IIa 139 65 46.76% 74 53.24%  
IIb 97 54 55.67% 43 44.33%  
IIIa 37 21 56.76% 16 43.24%  
IIIb 41 13 31.71% 28 68.29%  
IV 167 77 46.11% 90 53.89%  
Brain metastasis       0.000
Yes 180 60 33.33% 120 66.67%  
No 684 348 50.88% 336 49.12%  
Specimen type       0.000
Tissue 676 361 53.40% 315 46.60%  
Plasma 180 42 23.33% 138 76.67%  
Cytology 8 5 62.50% 3 37.50%  
Coal producing area       0.043
Yes 522 232 44.44% 290 55.56%  
No 342 176 51.46% 166 48.54%  
Fuyuan County origin       0.007
Yes 254 103 40.55% 151 59.45%  
No 610 305 50.00% 305 50.00%  
Xuanwei County origin       0.088
Yes 190 81 42.63% 109 57.37%  
No 674 327 48.52% 347 51.48%  
Total 864 408 47.22% 456 52.78%  
  1. AD adenocarcinoma, SCC squamous-cell carcinoma, ADSC adenosquamous carcinoma, LCC large cell carcinoma, NSCLC non-small-cell lung cancer
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Genes and Environment

ISSN: 1880-7062

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