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Table 3 Comparison of EGFR gene mutation frequency in the non-coal-producing areas subgroups and the coal-producing areas

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

  Coal-producing areas Non-coal-producing areas
Sum total Positive Negative p Sum total Positive Negative P
N % N % N % N %
Age       0.107       0.317
 < 65 427 197 46.14 230 53.86   245 130 53.06 115 46.94  
65–75 84 33 39.29 51 60.71   82 41 50.00 41 50.00  
 > 75 11 2 18.18 9 81.82   15 5 33.33 10 66.67  
Gender       0.000       0.000
Male 253 92 36.36 161 63.64   153 58 37.91 95 62.09  
Female 269 140 52.04 129 47.96   189 118 62.43 71 37.57  
Smoking history       0.000       0.003
Yes 134 39 29.10 95 70.90   69 25 36.23 44 63.77  
No 388 193 49.74 195 50.26   273 151 55.31 122 44.69  
Family history of malignant tumors       0.239       0.508
Yes 119 49 41.18 70 58.82   38 20 52.63 18 47.37  
No 403 183 45.41 220 54.59   304 156 51.32 148 48.68  
Histological and pathological type       0.076       0.000
AD 462 211 45.67 251 54.33   295 165 55.93 130 44.07  
Non-AD 60 21 35.00 39 65.00   47 11 23.40 36 76.60  
Tumor site       0.612       0.470
Left 198 92 46.46 106 53.54   128 66 51.56 62 48.44  
Right 307 134 43.65 173 56.35   207 108 52.17 99 47.83  
Bilateral 17 6 35.29 11 64.71   7 2 28.57 5 71.43  
Regional distribution       0.167       0.846
Central 65 39 60.00 26 40.00   165 86 52.12 79 47.88  
East 254 103 40.55 151 59.45   0 0 0.00 0 0.00  
Northeast 173 77 44.51 96 55.49   34 14 41.18 20 58.82  
Southeast 1 1 100.00 0 0.00   10 6 60.00 4 40.00  
South 6 2 33.33 4 66.67   8 4 50.00 4 50.00  
West 0 0 0.00 0 0.00   26 11 42.31 15 57.69  
Northwest 0 0 0.00 0 0.00   8 5 62.50 3 37.50  
Southwest 1 0 0.00 1 100.00   15 7 46.67 8 53.33  
North 8 4 50.00 4 50.00   57 33 57.89 24 42.11  
Other 14 6 42.86 8 57.14   19 10 52.63 9 47.37  
Ethnic group       0.400       0.515
Han 518 231 44.59 287 55.41   341 175 51.32 166 48.68  
Yi 4 1 25.00 3 75.00   1 1 100.00 0 0.00  
TNM staging       0.434       0.015
I-IIIa 381 168 44.09 213 55.91   275 150 54.55 125 45.45  
IIIb-IV 141 64 45.39 77 54.61   67 26 38.81 41 61.19  
Brain metastasis       0.110       0.000
Yes 46 16 34.78 30 65.22   55 8 14.55 47 85.45  
No 476 216 45.38 260 54.62   287 168 58.54 119 41.46  
Xuanwei County origin       0.331       0.182
Yes 157 67 42.68 90 57.32   33 14 42.42 19 57.58  
No 365 165 45.21 200 54.79   309 162 52.43 147 47.57  
Fuyuan County origin       0.049       NA
Yes 254 103 40.55 151 59.45   0 0 0.00 0 0.00  
No 268 129 48.13 139 51.87   342 176 51.46 166 48.54  
Total 522 232 44.44 290 55.56   342 176 51.46 166 48.54