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Table 3 Comparison of EGFR gene mutation frequency in the non-coal-producing areas subgroups and the coal-producing areas

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

 

Coal-producing areas

Non-coal-producing areas

Sum total

Positive

Negative

p

Sum total

Positive

Negative

P

N

%

N

%

N

%

N

%

Age

     

0.107

     

0.317

 < 65

427

197

46.14

230

53.86

 

245

130

53.06

115

46.94

 

65–75

84

33

39.29

51

60.71

 

82

41

50.00

41

50.00

 

 > 75

11

2

18.18

9

81.82

 

15

5

33.33

10

66.67

 

Gender

     

0.000

     

0.000

Male

253

92

36.36

161

63.64

 

153

58

37.91

95

62.09

 

Female

269

140

52.04

129

47.96

 

189

118

62.43

71

37.57

 

Smoking history

     

0.000

     

0.003

Yes

134

39

29.10

95

70.90

 

69

25

36.23

44

63.77

 

No

388

193

49.74

195

50.26

 

273

151

55.31

122

44.69

 

Family history of malignant tumors

     

0.239

     

0.508

Yes

119

49

41.18

70

58.82

 

38

20

52.63

18

47.37

 

No

403

183

45.41

220

54.59

 

304

156

51.32

148

48.68

 

Histological and pathological type

     

0.076

     

0.000

AD

462

211

45.67

251

54.33

 

295

165

55.93

130

44.07

 

Non-AD

60

21

35.00

39

65.00

 

47

11

23.40

36

76.60

 

Tumor site

     

0.612

     

0.470

Left

198

92

46.46

106

53.54

 

128

66

51.56

62

48.44

 

Right

307

134

43.65

173

56.35

 

207

108

52.17

99

47.83

 

Bilateral

17

6

35.29

11

64.71

 

7

2

28.57

5

71.43

 

Regional distribution

     

0.167

     

0.846

Central

65

39

60.00

26

40.00

 

165

86

52.12

79

47.88

 

East

254

103

40.55

151

59.45

 

0

0

0.00

0

0.00

 

Northeast

173

77

44.51

96

55.49

 

34

14

41.18

20

58.82

 

Southeast

1

1

100.00

0

0.00

 

10

6

60.00

4

40.00

 

South

6

2

33.33

4

66.67

 

8

4

50.00

4

50.00

 

West

0

0

0.00

0

0.00

 

26

11

42.31

15

57.69

 

Northwest

0

0

0.00

0

0.00

 

8

5

62.50

3

37.50

 

Southwest

1

0

0.00

1

100.00

 

15

7

46.67

8

53.33

 

North

8

4

50.00

4

50.00

 

57

33

57.89

24

42.11

 

Other

14

6

42.86

8

57.14

 

19

10

52.63

9

47.37

 

Ethnic group

     

0.400

     

0.515

Han

518

231

44.59

287

55.41

 

341

175

51.32

166

48.68

 

Yi

4

1

25.00

3

75.00

 

1

1

100.00

0

0.00

 

TNM staging

     

0.434

     

0.015

I-IIIa

381

168

44.09

213

55.91

 

275

150

54.55

125

45.45

 

IIIb-IV

141

64

45.39

77

54.61

 

67

26

38.81

41

61.19

 

Brain metastasis

     

0.110

     

0.000

Yes

46

16

34.78

30

65.22

 

55

8

14.55

47

85.45

 

No

476

216

45.38

260

54.62

 

287

168

58.54

119

41.46

 

Xuanwei County origin

     

0.331

     

0.182

Yes

157

67

42.68

90

57.32

 

33

14

42.42

19

57.58

 

No

365

165

45.21

200

54.79

 

309

162

52.43

147

47.57

 

Fuyuan County origin

     

0.049

     

NA

Yes

254

103

40.55

151

59.45

 

0

0

0.00

0

0.00

 

No

268

129

48.13

139

51.87

 

342

176

51.46

166

48.54

 

Total

522

232

44.44

290

55.56

 

342

176

51.46

166

48.54

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