Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

Wang, Jun-Ling; Fu, Yu-Dong; Gao, Yan-Hong; Li, Xiu-Ping; Xiong, Qian; Li, Rui; Hou, Bo; Huang, Ruo-Shan; Wang, Jun-Feng; Zhang, Jian-Kun; Lv, Jia-Ling; Zhang, Chao; Li, Hong-Wei

doi:10.1186/s41021-022-00248-z

Table 4 Incidence of EGFR gene mutation in the tissue and plasma subgroups

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

	Tissue						Plasma and pleural effusion cells
	Sum total	Positive		Negative		p	Sum total	Positive		Negative		p
	Sum total	N	%	N	%	p	Sum total	N	%	N	%	p
Age						0.520						0.894
< 65	551	296	53.72	255	46.28		121	31	25.62	90	74.38
65–75	114	61	53.51	53	46.49		52	13	25.00	39	75.00
> 75	11	4	36.36	7	63.64		15	3	20.00	12	80.00
Gender						0.000						0.014
Male	314	134	42.68	180	57.32		92	16	17.39	76	82.61
Female	362	227	62.71	135	37.29		96	31	32.29	65	67.71
Smoking history						0.000						0.011
Yes	159	59	37.11	100	62.89		44	5	11.36	39	88.64
No	517	302	58.41	215	41.59		144	42	29.17	102	70.83
Family history of malignant tumors						0.148						0.598
Yes	125	61	48.80	64	51.20		32	8	25.00	24	75.00
No	551	300	54.45	251	45.55		156	39	25.00	117	75.00
Histological and pathological type						0.003						0.459
AD	626	344	54.95	282	45.05		131	32	24.43	99	75.57
Non-AD	50	17	34.00	33	66.00		57	15	26.32	42	73.68
Tumor site						0.532						0.647
Left	252	137	54.37	115	45.63		74	21	28.38	53	71.62
Right	411	219	53.28	192	46.72		103	23	22.33	80	77.67
Bilateral	13	5	38.46	8	61.54		11	3	27.27	8	72.73
Regional distribution						0.102						0.192
Central	190	110	57.89	80	42.11		40	15	37.50	25	62.50
East	197	90	45.69	107	54.31		57	13	22.81	44	77.19
Northeast	158	81	51.27	77	48.73		49	10	20.41	39	79.59
Southeast	8	6	75.00	2	25.00		3	1	33.33	2	66.67
South	11	5	45.45	6	54.55		3	1	33.33	2	66.67
West	20	11	55.00	9	45.00		6	0	0.00	6	100.00
Northwest	7	4	57.14	3	42.86		1	1	100.00	0	0.00
Southwest	12	5	41.67	7	58.33		4	2	50.00	2	50.00
North	53	36	67.92	17	32.08		12	1	8.33	11	91.67
Other	20	13	65.00	7	35.00		13	3	23.08	10	76.92
Ethnic group						0.635						0.750
Han	672	359	53.42	313	46.58		1	0	0.00	1	100.00
Yi	4	2	50.00	2	50.00		187	47	25.13	140	74.87
TNM staging						0.447						0.083
I-IIIa	549	292	53.19	257	46.81		114	33	28.95	81	71.05
IIIb-IV	127	69	54.33	58	45.67		74	14	18.92	60	81.08
Brain metastasis						0.363						0.265
Yes	25	12	48.00	13	52.00		40	12	30.00	28	70.00
No	651	349	53.61	302	46.39		148	35	23.65	113	76.35
Coal-producing area						0.046						0.329
Yes	403	204	50.62	199	49.38		119	28	23.53	91	76.47
No	273	157	57.51	116	42.49		69	19	27.54	50	72.46
Fuyuan County origin						0.006						0.396
Yes	197	90	45.69	107	54.31		57	13	22.81	44	77.19
No	479	271	56.58	208	43.42		131	34	25.95	97	74.05
Xuanwei County origin						0.179						0.318
Yes	143	71	49.65	72	50.35		47	10	21.28	37	78.72
No	533	290	54.41	243	45.59		141	37	26.24	104	73.76
Total	676	361	53.40	315	46.60		188	47	25.00	141	75.00

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