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Table 4 Incidence of EGFR gene mutation in the tissue and plasma subgroups

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

  Tissue Plasma and pleural effusion cells
Sum total Positive Negative p Sum total Positive Negative p
N % N % N % N %
Age       0.520       0.894
 < 65 551 296 53.72 255 46.28   121 31 25.62 90 74.38  
65–75 114 61 53.51 53 46.49   52 13 25.00 39 75.00  
 > 75 11 4 36.36 7 63.64   15 3 20.00 12 80.00  
Gender       0.000       0.014
Male 314 134 42.68 180 57.32   92 16 17.39 76 82.61  
Female 362 227 62.71 135 37.29   96 31 32.29 65 67.71  
Smoking history       0.000       0.011
Yes 159 59 37.11 100 62.89   44 5 11.36 39 88.64  
No 517 302 58.41 215 41.59   144 42 29.17 102 70.83  
Family history of malignant tumors       0.148       0.598
Yes 125 61 48.80 64 51.20   32 8 25.00 24 75.00  
No 551 300 54.45 251 45.55   156 39 25.00 117 75.00  
Histological and pathological type       0.003       0.459
AD 626 344 54.95 282 45.05   131 32 24.43 99 75.57  
Non-AD 50 17 34.00 33 66.00   57 15 26.32 42 73.68  
Tumor site       0.532       0.647
Left 252 137 54.37 115 45.63   74 21 28.38 53 71.62  
Right 411 219 53.28 192 46.72   103 23 22.33 80 77.67  
Bilateral 13 5 38.46 8 61.54   11 3 27.27 8 72.73  
Regional distribution       0.102       0.192
Central 190 110 57.89 80 42.11   40 15 37.50 25 62.50  
East 197 90 45.69 107 54.31   57 13 22.81 44 77.19  
Northeast 158 81 51.27 77 48.73   49 10 20.41 39 79.59  
Southeast 8 6 75.00 2 25.00   3 1 33.33 2 66.67  
South 11 5 45.45 6 54.55   3 1 33.33 2 66.67  
West 20 11 55.00 9 45.00   6 0 0.00 6 100.00  
Northwest 7 4 57.14 3 42.86   1 1 100.00 0 0.00  
Southwest 12 5 41.67 7 58.33   4 2 50.00 2 50.00  
North 53 36 67.92 17 32.08   12 1 8.33 11 91.67  
Other 20 13 65.00 7 35.00   13 3 23.08 10 76.92  
Ethnic group       0.635       0.750
Han 672 359 53.42 313 46.58   1 0 0.00 1 100.00  
Yi 4 2 50.00 2 50.00   187 47 25.13 140 74.87  
TNM staging       0.447       0.083
I-IIIa 549 292 53.19 257 46.81   114 33 28.95 81 71.05  
IIIb-IV 127 69 54.33 58 45.67   74 14 18.92 60 81.08  
Brain metastasis       0.363       0.265
Yes 25 12 48.00 13 52.00   40 12 30.00 28 70.00  
No 651 349 53.61 302 46.39   148 35 23.65 113 76.35  
Coal-producing area       0.046       0.329
Yes 403 204 50.62 199 49.38   119 28 23.53 91 76.47  
No 273 157 57.51 116 42.49   69 19 27.54 50 72.46  
Fuyuan County origin       0.006       0.396
Yes 197 90 45.69 107 54.31   57 13 22.81 44 77.19  
No 479 271 56.58 208 43.42   131 34 25.95 97 74.05  
Xuanwei County origin       0.179       0.318
Yes 143 71 49.65 72 50.35   47 10 21.28 37 78.72  
No 533 290 54.41 243 45.59   141 37 26.24 104 73.76  
Total 676 361 53.40 315 46.60   188 47 25.00 141 75.00