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Table 5 Incidence of EGFR gene mutation in adenocarcinoma subgroup

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

  Sum total Positive Negative p
N % N %
Age       0.868
 < 65 605 302 49.92 303 50.08  
65–75 138 68 49.28 70 50.72  
 > 75 14 6 42.86 8 57.14  
Gender       0.000
Male 343 137 39.94 206 60.06  
Female 414 239 57.73 175 42.27  
Smoking history       0.000
Yes 170 60 35.29 110 64.71  
No 587 316 53.83 271 46.17  
Family history of malignant tumors       0.117
Yes 149 67 44.97 82 55.03  
No 608 309 50.82 299 49.18  
Tumor site       0.316
Left 278 144 51.80 134 48.20  
Right 459 225 49.02 234 50.98  
Bilateral 20 7 35.00 13 65.00  
Regional distribution       0.027
Central 199 117 58.79 82 41.21  
East 227 96 42.29 131 57.71  
Northeast 180 80 44.44 100 55.56  
Southeast 9 6 66.67 3 33.33  
South 14 6 42.86 8 57.14  
West 20 10 50.00 10 50.00  
Northwest 8 5 62.50 3 37.50  
Southwest 12 5 41.67 7 58.33  
North 59 36 61.02 23 38.98  
Other 29 15 51.72 14 48.28  
Ethnic group       0.683
Han 753 374 49.67 379 50.33  
Yi 4 2 50.00 2 50.00  
TNM staging       0.278
I-IIIa 582 293 50.34 289 49.66  
IIIb-IV 175 83 47.43 92 52.57  
Brain metastasis       0.023
Yes 51 18 35.29 33 64.71  
No 706 358 50.71 348 49.29  
Specimen type       0.000
Tissue 626 344 54.95 282 45.05  
Plasma 127 31 24.41 96 75.59  
Cytology 4 1 25.00 3 75.00  
Coal producing area       0.004
Yes 462 211 45.67 251 54.33  
No 295 165 55.93 130 44.07  
Fuyuan County origin       0.005
Yes 227 96 42.29 131 57.71  
No 530 280 52.83 250 47.17  
Xuanwei County origin       0.027
Yes 166 71 42.77 95 57.23  
No 591 305 51.61 286 48.39  
Total 757 376 49.67 381 50.33