Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

Table 5 Incidence of EGFR gene mutation in adenocarcinoma subgroup

	Sum total	Positive		Negative		p
	Sum total	N	%	N	%	p
Age						0.868
< 65	605	302	49.92	303	50.08
65–75	138	68	49.28	70	50.72
> 75	14	6	42.86	8	57.14
Gender						0.000
Male	343	137	39.94	206	60.06
Female	414	239	57.73	175	42.27
Smoking history						0.000
Yes	170	60	35.29	110	64.71
No	587	316	53.83	271	46.17
Family history of malignant tumors						0.117
Yes	149	67	44.97	82	55.03
No	608	309	50.82	299	49.18
Tumor site						0.316
Left	278	144	51.80	134	48.20
Right	459	225	49.02	234	50.98
Bilateral	20	7	35.00	13	65.00
Regional distribution						0.027
Central	199	117	58.79	82	41.21
East	227	96	42.29	131	57.71
Northeast	180	80	44.44	100	55.56
Southeast	9	6	66.67	3	33.33
South	14	6	42.86	8	57.14
West	20	10	50.00	10	50.00
Northwest	8	5	62.50	3	37.50
Southwest	12	5	41.67	7	58.33
North	59	36	61.02	23	38.98
Other	29	15	51.72	14	48.28
Ethnic group						0.683
Han	753	374	49.67	379	50.33
Yi	4	2	50.00	2	50.00
TNM staging						0.278
I-IIIa	582	293	50.34	289	49.66
IIIb-IV	175	83	47.43	92	52.57
Brain metastasis						0.023
Yes	51	18	35.29	33	64.71
No	706	358	50.71	348	49.29
Specimen type						0.000
Tissue	626	344	54.95	282	45.05
Plasma	127	31	24.41	96	75.59
Cytology	4	1	25.00	3	75.00
Coal producing area						0.004
Yes	462	211	45.67	251	54.33
No	295	165	55.93	130	44.07
Fuyuan County origin						0.005
Yes	227	96	42.29	131	57.71
No	530	280	52.83	250	47.17
Xuanwei County origin						0.027
Yes	166	71	42.77	95	57.23
No	591	305	51.61	286	48.39
Total	757	376	49.67	381	50.33

ISSN: 1880-7062