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Table 6 Types of EGFR gene mutations identified in this study

From: Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China

  Coal-producing areas Specimen type Gender Smoking history
Total Yes No   Tissue Plasma and pleural effusion cells Male Female   Yes No  
N % N % N % p N % N % p N % N % p N % N % p
Sensitizing mutations
 L858R 135 33.09 63 27.16 72 40.91 0.003 119 32.96 16 34.04 0.882 45 30.00 90 34.88 0.31 14 21.88 121 35.17 0.038
 19-del 87 21.32 41 17.67 46 26.14 0.039 77 21.33 10 21.28 0.993 30 20.00 57 22.09 0.62 13 20.31 74 21.51 0.830
 G719X 29 7.11 23 9.91 6 3.41 0.011 25 6.93 4 8.51 0.923 9 6.00 20 7.75 0.51 6 9.38 23 6.69 0.614
 G719X + L861X 10 2.45 4 1.72 6 3.41 0.443 10 2.77 0 0.00 0.513 3 2.00 7 2.71 0.91 1 1.56 9 2.62 0.952
 L861Q 6 1.47 2 0.86 4 2.27 0.224 4 1.11 2 4.26 0.144 1 0.67 5 1.94 0.29 1 1.56 5 1.45 0.643
 L858R + L833F 4 0.98 4 1.72 0 0.00 0.103 4 1.11 0 0.00 0.612 1 0.67 3 1.16 0.53 1 1.56 3 0.87 0.496
 G719X + E709X 4 0.98 3 1.29 1 0.57 0.421 4 1.11 0 0.00 0.612 1 0.67 3 1.16 0.53 0 0.00 4 1.16 0.504
 L861X + L833F 4 0.98 3 1.29 1 0.57 0.421 4 1.11 0 0.00 0.612 2 1.33 2 0.78 0.47 1 1.56 3 0.87 0.496
 L858R + EGFR gene ampilification 3 0.74 2 0.86 1 0.57 0.603 3 0.83 0 0.00 0.692 1 0.67 2 0.78 0.69 0 0.00 3 0.87 0.599
 EGFR gene ampilification 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 1 0.67 0 0.00 0.37 1 1.56 0 0.00 0.157
 G719X + L858R 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 0 0.00 1 0.39 0.63 0 0.00 1 0.29 0.843
 L833V + H835L 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 1 0.67 0 0.00 0.37 1 1.56 0 0.00 0.157
 18-del 1 0.25 0 0.00 1 0.57 0.431 1 0.28 0 0.00 0.885 1 0.67 0 0.00 0.37 0 0.00 1 0.29 0.843
 19-del + EGFR gene ampilification 3 0.74 0 0.00 3 1.70 0.079 3 0.83 0 0.00 0.692 1 0.67 2 0.78 0.69 1 1.56 2 0.58 0.401
 L858R + E709X 1 0.25 0 0.00 1 0.57 0.431 1 0.28 0 0.00 0.885 0 0.00 1 0.39 0.63 0 0.00 1 0.29 0.843
 L861Q + L838V 1 0.25 0 0.00 1 0.57 0.431 1 0.28 0 0.00 0.885 1 0.67 0 0.00 0.37 1 1.56 0 0.00 0.157
Resistance mutations
 20INS 14 3.43 5 2.16 9 5.11 0.104 13 3.60 1 2.13 0.923 6 4.00 8 3.10 0.63 3 4.69 11 3.20 0.820
 S768I 5 1.23 5 2.16 0 0.00 0.058 4 1.11 1 2.13 0.459 2 1.33 3 1.16 0.61 1 1.56 4 1.16 0.576
 T790M 3 0.74 3 1.29 0 0.00 0.183 1 0.28 2 4.26 0.036 2 1.33 1 0.39 0.31 1 1.56 2 0.58 0.401
 L747S 1 0.25 0 0.00 1 0.57 0.431 1 0.28 0 0.00 0.885 0 0.00 1 0.39 0.63 0 0.00 1 0.29 0.843
Combination of sensitizing and resistance mutations
 G719X + S768I 68 16.67 56 24.14 12 6.82 0.000 61 16.90 7 14.89 0.729 30 20.00 38 14.73 0.17 14 21.88 54 15.70 0.223
 S768I + L858R 4 0.98 3 1.29 1 0.57 0.421 4 1.11 0 0.00 0.612 2 1.33 2 0.78 0.47 1 1.56 3 0.87 0.496
 19-del + T790M 3 0.74 1 0.43 2 1.14 0.397 2 0.55 1 2.13 0.308 2 1.33 1 0.39 0.31 1 1.56 2 0.58 0.401
 L858R + T790M 3 0.74 1 0.43 2 1.14 0.397 3 0.83 0 0.00 0.692 0 0.00 3 1.16 0.25 0 0.00 3 0.87 0.599
 19-del + S768I 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 0 0.00 1 0.39 0.63 0 0.00 1 0.29 0.843
 G719X + S768I + L858R 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 1 0.67 0 0.00 0.37 1 1.56 0 0.00 0.157
 G719X + S768I + EGFR gene ampilification 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 0 0.00 1 0.39 0.63 0 0.00 1 0.29 0.843
 L858R + 20INS 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 1 0.67 0 0.00 0.37 0 0.00 1 0.29 0.843
 G719X + D761Y + EGFR gene ampilification 1 0.25 1 0.43 0 0.00 0.569 1 0.28 0 0.00 0.885 1 0.67 0 0.00 0.37 0 0.00 1 0.29 0.843
 19-del + T790M + C797S 1 0.25 0 0.00 1 0.57 0.431 0 0.00 1 2.13 0.115 0 0.00 1 0.39 0.63 0 0.00 1 0.29 0.843
 G719X + S768I + T790M 1 0.25 0 0.00 1 0.57 0.431 0 0.00 1 2.13 0.115 0 0.00 1 0.39 0.63 0 0.00 1 0.29 0.843
 L858R + T790M + EGFR gene ampilification 1 0.25 0 0.00 1 0.57 0.431 0 0.00 1 2.13 0.115 1 0.67 0 0.00 0.37 0 0.00 1 0.29 0.843
No EGFR targeted therapies mutations
 V769fs,S1042I,H773L,V774M,G983W,D1127fs,R973Q,I926L,A1118V 8 1.96 5 2.16 3 1.70 0.521 8 2.22 0 0.00 0.372 4 2.67 4 1.55 0.68 1 1.56 7 2.03 0.802