Table 1 Histopathological findings in the liver
From: The effect of aging on the repeated-dose liver micronucleus assay using diethylnitrosamine
Age at the end of dosing: | 8 weeks | 10 weeks | |||||||
|---|---|---|---|---|---|---|---|---|---|
Dose (mg/kg): | 0 | 3.13 | 6.25 | 12.5 | 0 | 3.13 | 6.25 | 12.5 | |
Findings | No. of animals examined: | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
Single cell necrosis, hepatocytes, centrilobular | 0 | 4 | 5 | 5 | 0 | 3 | 5 | 5 | |
minimal | – | 4 | 3 | – | – | 3 | 2 | – | |
mild | – | – | 2 | 5 | – | – | 3 | 5 | |
Karyomegaly, hepatocyte, centrilobular | 0 | 3 | 5 | 5 | 0 | 3 | 5 | 5 | |
minimal | – | 3 | 2 | – | – | 3 | 2 | – | |
mild | – | – | 3 | 4 | – | – | 3 | 3 | |
moderate | – | – | – | 1 | – | – | – | 2 | |
Mitosis, increased, hepatocyte | 0 | 0 | 2 | 5 | 0 | 0 | 2 | 5 | |
minimal | – | – | 2 | 5 | – | – | 2 | 4 | |
mild | – | – | – | – | – | – | – | 1 | |