Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse

Table 1 Incidence and average size of lung nodules of the left lung lobe in mice

Group	Treatment	n	Average body weight (g) at 30 wks	% of mice with nodules	No. of nodules per mouse	Average size of nodules (mm)
Exp. 1
I	NNK ip + water	16	25.2 ± 2.2	100	5.14 ± 1.46	1.28 ± 0.22
II	NNK ip + sar-j	15	20.3 ± 0.94	53.3	0.733 ± 0.799*	1.18 ± 0.13
III	saline ip + sar-j	15	22.4 ± 2.4	0	0 ± 0	0 ± 0
Exp.2
IV	NNK ip + water	15	29.5 ± 3.48	100	3.67 ± 2.23	1.43 ± 0.382
V	NNK ip + isoQ 10 mM¹	10	31.5 ± 3.84	100	3.50 ± 1.08	1.43 ± 0.274
VI	NNK ip + isoQ 25 mM¹	10	32.2 ± 2.20	90	2.00 ± 1.41^#	1.42 ± 0.328
VII	saline ip + isoQ 25 mM¹	5	35.9 ± 3.40	0	0	0
VIII	saline ip + water	10	32.7 ± 3.64	0	0	0

ISSN: 1880-7062